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中华胃肠内镜电子杂志 ›› 2018, Vol. 05 ›› Issue (04) : 167 -173. doi: 10.3877/cma.j.issn.2095-7157.2018.04.006

所属专题: 文献

综述

寡肽吸收的研究进展
王宁1, 令狐恩强1,()   
  1. 1. 100853 北京,解放军总医院消化科
  • 收稿日期:2018-08-31 出版日期:2018-11-15
  • 通信作者: 令狐恩强
  • 基金资助:
    北京市科委课题(D141100000414003)

Advances in oligopeptides absorption

Ning Wang1, Enqiang Linghu1,()   

  1. 1. Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2018-08-31 Published:2018-11-15
  • Corresponding author: Enqiang Linghu
  • About author:
    Corresponding author: Linghu Enqiang, Email:
引用本文:

王宁, 令狐恩强. 寡肽吸收的研究进展[J/OL]. 中华胃肠内镜电子杂志, 2018, 05(04): 167-173.

Ning Wang, Enqiang Linghu. Advances in oligopeptides absorption[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2018, 05(04): 167-173.

蛋白质在动物消化道内经过各种消化酶的作用,被降解成游离氨基酸和寡肽。自20世纪60年代起大量研究表明,除了游离氨基酸以外,寡肽尤其是小肽也能够被动物直接吸收利用。寡肽可通过细胞旁途径、被动扩散、内吞作用或载体转运后被小肠上皮细胞吸收。其生物活性在口服药物吸收中也有广泛的应用前景。影响寡肽吸收转运的因素主要有:采食水平、蛋白质品质、肽链长度、氨基酸残基构型、载体及动物健康状态等。

Proteins can be digested into free amino acids and oligopeptides by various enzymes in the gastrointestinal tract. It has been recognized that oligopeptides, especially small peptides, can be directly absorbed and utilized by animals since the 1960s. The oligopeptides can be absorbed by small intestinal epithelial cells through paracellular pathway, passive diffusion, endocytosis or carrier transport. Its biological activity also has a wide application prospect in oral drug delivery. The main influencing factors are feeding level, protein quality, length of peptide chain, configuration of amino acid residues, carrier and animal health status, etc..

图1 蛋白质在哺乳动物小肠上皮细胞的消化吸收过程[14]
图2 寡肽通过小肠上皮细胞的路径[1]
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