切换至 "中华医学电子期刊资源库"

中华胃肠内镜电子杂志 ›› 2019, Vol. 06 ›› Issue (02) : 86 -88. doi: 10.3877/cma.j.issn.2095-7157.2019.02.009

所属专题: 文献

综述

放射性肠炎中微血管损伤机制及与内镜表现的关系
张跃伟1, 李长政1,()   
  1. 1. 100088 北京,火箭军特色医学中心消化科
  • 收稿日期:2019-05-06 出版日期:2019-05-15
  • 通信作者: 李长政

The mechanism of microvessel damage and its relationship with endoscopic findings in radiation enteritis

Yuewei Zhang1, Changzheng Li1,()   

  1. 1. Department of Gastroenterology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China
  • Received:2019-05-06 Published:2019-05-15
  • Corresponding author: Changzheng Li
  • About author:
    Corresponding author: Li Changzheng, Email:
引用本文:

张跃伟, 李长政. 放射性肠炎中微血管损伤机制及与内镜表现的关系[J/OL]. 中华胃肠内镜电子杂志, 2019, 06(02): 86-88.

Yuewei Zhang, Changzheng Li. The mechanism of microvessel damage and its relationship with endoscopic findings in radiation enteritis[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2019, 06(02): 86-88.

放射性肠炎内镜下常具有黏膜下毛细血管网减少,残留血管异常扩张等较特征性表现。本文主要介绍放射性肠炎中微血管损伤的机制,包括微血管密度下降、黏膜下纤维化、异常新生血管等与内镜下表现的关系,以期为临床治疗放射性肠炎提供新的思路。

Radiation enteritis always showed characteristic decreased capillary network and abnormal dilated vessels at endoscopy.This article mainly reviewed the mechanism of microvessel damage, including the relationship of decreased microvessel density, submucosal fibrosis, abnormal neovascularization with cytokines and inflammatory mediators.These relationships may provide new idea in treatment of radiation enteritis.

[1]
HauerjensenM,DenhamJW,AndreyevHJN.Radiation enteropathy-pathogenesis,treatment and prevention[J].Nat Rev Gastroenterol Hepatol,2014,11(10):470-479.
[2]
ChaoY,DaiWM,ChenHX,et al.Application of human bone marrow-derived mesenchymal stem cells in the treatment of radiation-induced Gastrointestinal syndrome[J].Science China Life Sciences,2014,57(12):1177-1182.
[3]
谢静,李长政.放射性肠炎的内镜特点和治疗[J/CD].中华胃肠内镜电子杂志,2018(3):124-126.
[4]
SlezakJ,KuraB,Ravingerová,Táňa,et al.Mechanisms of cardiac radiation injury and potential preventive approaches[J].Can J Physiol Pharmacol,2015:1-17.
[5]
BakerDG,KrochakRJ.The response of the microvascular system to radiation:a review[J].Cancer Invest,1989,7(3):287-294.
[6]
LeeMS,FinchW,MahmudE.Cardiovascular Complications of Radiotherapy[J].Am J Cardiol,2013,112(10):1688-1696.
[7]
Fran?ois Paris,FuksZ,KangA,et al.Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice[J].Science,2001,293(5528):293-297.
[8]
BakerJE,FishBL,SuJ,et al.10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model[J].Int J Rad Biol,2009,85(12):1089-1100.
[9]
StewartFA,HovingS,RussellNS.Vascular Damage as an Underlying Mechanism of Cardiac and Cerebral Toxicity in Irradiated Cancer Patients[J].Rad Res,2010,174(6b):865-869.
[10]
KawanoS,KubotaT,MondenY,et al.Blockade of NF-kappa B improves cardiac function and survival after myocardial infarction[J].Am J Physiol Heart Circ Physiol,2006,291(3):H1337.
[11]
SbragiaL,SchmidtAF,MoraesS,et al.Inflammatory response in a rat model of gastroschisis is associated with an increase of NF-kappaB[J].Br J Med Biol Res,2010,43(2):160-165.
[12]
BeenkenA,MohammadiM.The FGF family:biology, pathophysiology and therapy[J].Nat Rev Drug Discov,2009,8(3):235-253.
[13]
WangJ,BoermaM,FuQ, et al. Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy[J].World J Gastroenterol,2007,13(22):3047-3055.
[14]
StansboroughRL,BatemanEH,NoorAD,et al.Vascular endothelial growth factor (VEGF),transforming growth factor beta (TGFβ),angiostatin,and endostatin are increased in radiotherapy-induced gastrointestinal toxicity[J].Int J Rad Biol,2018:1-30.
[15]
Charlotte T,BäckSven,LenaW,et al.Local radiotherapy of exposed murine small bowel:Apoptosis and inflammation[J].BMC Surgery,2008,8:1.
[1] 于桐, 孙姗姗, 刘扬. 乳腺导管原位癌的浸润转化机制及临床病理特征[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 304-307.
[2] 李蓉. 薄型子宫内膜治疗新方法[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 591-591.
[3] 严华悦, 刘子祥, 周少波. 磷酸烯醇式丙酮酸羧激酶-1在恶性肿瘤中的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(06): 452-456.
[4] 刘璐璐, 何羽. 慢性阻塞性肺病患者睡眠障碍的研究进展[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 836-839.
[5] 袁园园, 岳乐淇, 张华兴, 武艳, 李全海. 间充质干细胞在呼吸系统疾病模型中肺组织分布及治疗机制的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 374-381.
[6] 王庭宇, 邵联波, 刘珊, 沈振亚. Stanford A 型主动脉夹层相关基因KIF20A 的共表达网络构建及作用靶点分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 303-312.
[7] 陈丽璇, 窦培宁, 肖扬. 干细胞治疗早发性卵巢功能不全的现状及未来展望[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(04): 239-248.
[8] 孟煜凡, 李永政, 樊知遥, 展翰翔. 瘤内微生物在胰腺癌发病和演进中的作用机制及研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 577-582.
[9] 赵泽云, 李建男, 王旻. 中性粒细胞胞外诱捕网在结直肠癌中的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 524-528.
[10] 王梦琪, 刘恒昌, 陈海鹏, 刘佳. 骶神经刺激治疗排便失禁的机制研究进展[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 417-422.
[11] 李元新, 徐田磊, 刘伯涛. 第四代达芬奇机器人辅助慢性放射性肠炎确定性手术一例(附视频)[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 435-440.
[12] 陈利, 杨长青, 朱风尚. 重视炎症性肠病和代谢相关脂肪性肝病间的串话机制研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 385-389.
[13] 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845.
[14] 徐靖亭, 孔璐. PARP抑制剂治疗卵巢癌的耐药机制及应对策略[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 584-588.
[15] 曹亚丽, 高雨萌, 张英谦, 李博, 杜军保, 金红芳. 儿童坐位不耐受的临床进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 510-515.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?