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中华胃肠内镜电子杂志 ›› 2024, Vol. 11 ›› Issue (01) : 18 -22. doi: 10.3877/cma.j.issn.2095-7157.2024.01.005

论著

大肠黑变病与侧向生长型肿瘤的临床研究
温栋惠1, 张克1, 张昊1, 马连君1, 张斌1,()   
  1. 1. 130033 长春,吉林大学中日联谊医院胃肠内科(内镜中心)
  • 收稿日期:2024-01-16 出版日期:2024-02-15
  • 通信作者: 张斌
  • 基金资助:
    吉林省发改委资助项目(3J1196575429)

Clinical study on melanosis coli and laterally spreading tumors

Donghui Wen1, Ke Zhang1, Hao Zhang1, Lianjun Ma1, Bin Zhang1,()   

  1. 1. Department of Gastroenterology(Endoscopy Center), China-Japan Union Hospital of Jilin University, Changchun 130033, China
  • Received:2024-01-16 Published:2024-02-15
  • Corresponding author: Bin Zhang
引用本文:

温栋惠, 张克, 张昊, 马连君, 张斌. 大肠黑变病与侧向生长型肿瘤的临床研究[J]. 中华胃肠内镜电子杂志, 2024, 11(01): 18-22.

Donghui Wen, Ke Zhang, Hao Zhang, Lianjun Ma, Bin Zhang. Clinical study on melanosis coli and laterally spreading tumors[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2024, 11(01): 18-22.

目的

探讨大肠黑变病(MC)与侧向生长型肿瘤(LST)是否有关联,以及MC的癌变风险。

方法

回顾性研究我院2018年至2022年结肠镜诊断为MC的患者,使用倾向匹配得分(PSM),将年龄、性别作为匹配变量,进行MC组和对照组的1∶2最邻近匹配,最终共入组361例MC与722例对照,分析LST与MC的关系。

结果

MC组与对照组的LST检出率分别为10.7%和6.2%(P=0.040),进一步行二元Logistic回归分析显示,MC与LST检出率增加显著相关(OR:1.487,95%CI: 1.096~2.012,P=0.010)。此外,MC中的LST恶变率增高(P=0.026),二元Logistic回归分析证明MC为LST恶变的危险因素(OR:1.825,95%CI: 1.276~2.611,P=0.001)。LST的检出与MC的分布(P=0.005)、级别(P=0.045)相关。

结论

MC中LST检出率增高,且LST恶性肿瘤发生率增高。

Objective

To explore whether melanosis coli (MC) and is associated with laterally spreading tumors (LST), and the cancer risk.

Methods

We conducted a retrospective study involving patients diagnosed with melanosis coli through colonoscopy at our hospital between 2018 and 2022, and propensity matching scores (PSM) were performed. Age and gender were used as matching variables to perform 1∶2 nearest-neighbor matching between the MC group and the control group. A total of 361 MC patients and 722 controls were enrolled in the study, and our analysis sought to examine the relationship between LST and MC.

Results

The LST detection rates in the MC and control groups were 10.7% and 6.2%, respectively (P=0.040), and further binary logistic regression analysis showed that MC was significantly correlated with an increased LST detection rate (OR: 1.487, 95%CI: 1.096-2.012, P=0.010). In addition, the rate of LST malignancy was increased in MC (P=0.026), and binary logistic regression analysis demonstrated that MC was a risk factor for LST malignancy (OR: 1.825, 95%CI: 1.276-2.611, P=0.001). LST detection was correlated with the distribution (P=0.005), and grade (P=0.045) of MC.

Conclusion

The detection rate of LST is higher in MC compared to the control group, and the incidence of LST malignancy is higher in MC.

图1 MC中的LST注:A:MC Ⅰ级;B:MC Ⅱ级;C: MC Ⅲ级
表1 患者和对照组的基线特征的对比[例(%)]
表2 LST检出相关因素的二元Logistic回归分析
表3 MC中的LST的特征[例(%)]
表4 LST恶变相关因素的二元Logistic回归分析
表5 有无检出LST的MC的对比[例(%)]
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