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中华胃肠内镜电子杂志 ›› 2019, Vol. 06 ›› Issue (03) : 133 -137. doi: 10.3877/cma.j.issn.2095-7157.2019.03.009

所属专题: 文献

综述

幽门螺杆菌主要毒力因子及其与胃癌关系的研究进展
刘榕1, 高孝忠2,()   
  1. 1. 264003 山东,滨州医学院;264200 山东,威海市立医院
    2. 264200 山东,威海市立医院
  • 收稿日期:2019-08-02 出版日期:2019-08-15
  • 通信作者: 高孝忠

The progress of relationship between Helicobacter pylori main virulence factors and gastric cancer

Rong Liu1, Xiaozhong Gao2,()   

  1. 1. Binzhou Medical University, 264003 Shandong;Weihai Municipal Hospital 264200 Weihai, China
    2. Weihai Municipal Hospital 264200 Weihai, China
  • Received:2019-08-02 Published:2019-08-15
  • Corresponding author: Xiaozhong Gao
  • About author:
    Corresponding author: Gao Xiaozhong, Email:
引用本文:

刘榕, 高孝忠. 幽门螺杆菌主要毒力因子及其与胃癌关系的研究进展[J/OL]. 中华胃肠内镜电子杂志, 2019, 06(03): 133-137.

Rong Liu, Xiaozhong Gao. The progress of relationship between Helicobacter pylori main virulence factors and gastric cancer[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2019, 06(03): 133-137.

幽门螺杆菌(Hp)感染被定义为感染性疾病已在全球达成共识,其与胃癌的发生、发展密切相关,本文将从Hp主要毒力因子VacA、CagA与胃癌的关系,根除Hp感染对预防胃癌及其机制的研究进展作一综述。

Helicobacter pylori infection is defined as an infectious disease by global consensus, which is closely related to the occurrence and development of gastric cancer.In this paper, we reviewed the relationship between the main virulence factors VacA, CagA and gastric cancer, the effect and its mechanism of Hp eradication on the prevention of gastric cancer.

[1]
Bray F, Ferlay J, Soerjtaram I,et al.Global cancer statistics 2018:Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].Cancer Clin,2018: 21492.
[2]
Malfertheiner P, Megraud F, O'Morain CA,et al.Management of Helicobacter pyloriinfection-the Maastricht V/Florence Consensus Report[J].Gut,2017,66(1): 6-30.
[3]
Yoon H, Kim N, Lee HS,et al.Helicobacter pylori-negative gastric cancer in South Korea:incidence and clinicopathologic characteristics [J].Helicobacter,2011,16(5): 382-388.
[4]
Sergio AC, Hiroaki T, Gil RC-C,et al.Role of bacterial and genetic factors in gastric cancer in Costa Rica[J].World J Gastroenterol,2009,15(2): 211-218.
[5]
Roman-Roman A, Martinez Carrillo DN, Atrisco-Morales J,et al.Helicobacter pylori VacA s1m1 genotype but not CagA or BabA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico[J].Gut Pathog,2017,9(1): 18-29.
[6]
Matos JI, Marcos-Pinto R, Dinis-Ribeiro M.Helicobacter pylori CagA and VacA genotypes and gastric phenotype:a meta-analysis[J].Gastroenterol Hepatol,2013,25(12): 1431-1441.
[7]
Li Q, Liu J, Gong Y, Yuan Y. Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks:a meta analysis[J].Medicine (Baltimore),2017,96(17): e6620.
[8]
Sinnett CG, Letley DP, Narayanan GL,et al. Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy[J].Clin Pathol,2016,69(11): 968-973.
[9]
Aasen T, Mesnil M, Naus CC,et al.Gap junctions and cancer:Communicating for 50 years[J].Nat Rev Cancer,2016,16(12): 775-788.
[10]
Ogiwara H, Graham DY, Yamaoka Y.VacAi-region subtyping[J]. Gastroenterology,2008,134(4): 1267-1276.
[11]
Gonzalez CA, Figueiredo C, Ferreira RM,et al.Helicobacter pylori cagA and VacA genotypes as predictors of progression of gastric preneoplastic lesions: a long-term follow-up in a high-risk area in Spain[J].Gastroenterology,2011,106(5): 867-874.
[12]
曹世堂,易小兵,王玉华,等.幽门螺旋杆菌感染与胃癌组织中p27、CyclinD1、MIF蛋白表达的相关性分析[J].实用医院临床杂志,2017,14(5): 154-157.
[13]
Vogelmann R, Covacci A, Falkow S,et al.Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA[J].Science,2003,300: 1430-1434.
[14]
Wang F, Xia P, Wu F,et al.Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells[J].Biol Chem,2008,283: 26714-26725.
[15]
Lina TT, Alzahrani S, Gonzalez J,et al.Immune evasion strategies used by Helicobacter pylori[J].World J Gastroenterol,2014,20(36): 12753-12766.
[16]
Skibinski DA, Genisset C, Barone S, Telford JL.The cell-specifific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase beta[J].Infect Immun,2006,74(1): 49-55.
[17]
Gonzalez-Rivera C, Algood HM, Radin JN,et al.The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay[J].Infect Immun,2012,80(8): 2578-2588.
[18]
Tegtmeyer N, Neddermann M, Asche CI,et al.Subversion of host kinases:A key network in cellular signaling hijacked by Helicobacter pylori CagA[J].Mol Microbiol,2017,105(3): 358-372.
[19]
雍鑫.CagA阳性幽门螺杆菌在促胃癌细胞干性特征增强中的作用及其机制研究[D].第三军医大学,2016.
[20]
Buti L, Spooner E, Rappuoli R,et al.Helicobacter pylori cytotoxin-associated gene A(CagA)subverts the apoptosis stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host[J].Proc Natl Acad Sci,2011,108(22): 9238-9243.
[21]
Kaplan-Turkoz B, Dian C, Ertl C,et al.Structural insights into Helicobacter pylori oncoprotein CagA interaction with beta1 integrin[J].Proc Natl Acad Sci,2012,109(36): 14640-14645.
[22]
Akada J, Kitagawa T, Kurazono H,et al.Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells[J].Dis Models Mech,2010,3(9-10): 605-617.
[23]
Park YH, Kim N.Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer[J].Cancer Prev,2015,20(1): 25-40.
[24]
Hwang YJ, Kim N, Lee HS,et al.Reversibility of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication-a prospective study for up to 10 years[J].Aliment Pharmacol Ther,2017,47(3): 380-390.
[25]
Sonnenberg A. Review article: historic changes of Helicobacter pylori associated diseases[J].Aliment Pharmacol Ther,2013,38(4): 329-342.
[26]
Kim N, Park YS, Cho SI, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease[J].Helicobacter,2008,13(4): 245-55.
[27]
Houghton J, Stoicov C, Nomura S,et al.Gastric cancer originating from bone marrowderived cells[J].Science,2004,306(5701): 1568-1571.
[28]
Kim YI, Choi IJ, Kook MC,et al.The association between Helicobacter pylori status and incidence of metachronous gastric cancer after endoscopic resection of early gastric cancer[J].Helicobacter,2014,19(3): 194-201.
[29]
Wong BC, Lam SK, Wong WM,et al.Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China:a randomized controlled trial[J].JAMA,2004,291(2): 187-194.
[30]
Shichijo S, Hirata Y, Niikura R,et al.Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication[J].Gastrointest Endosc,2016,84(4): 618-624.
[31]
Lee YC, Chiang TH, Chou CK,et al.Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence:A Systematic Review and Meta-analysis[J].Gastroenterology,2016,150(5): 1113-1124.
[32]
Tsuda M, Asaka M, Kato M,et al.Effect on Helicobacter pylori eradication therapy against gastric cancer in Japan[J].Helicobacter,2017,22(5): e12415.
[33]
Mera RM, Bravo LE, Camargo MC,et al.Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions:16-year follow-up of an eradication trial[J].Gut,2018,67(7): 1239-1246.
[34]
Bae SE, Choi KD, Choe J,et al.The effect of eradication of Helicobacter pylori on gastric cancer prevention in healthy asymptomatic populations[J]. Helicobacter,2018,e12464.
[35]
Bae SE, Jung HY, Kang J,et al.Effect of Helicobacter pylori eradication on metachronous recurrence after endoscopic resection of gastric neoplasm[J].Gastroenterol,2014,109(1): 60-67.
[36]
Kiriyama Y, Tahara T, Shibata T,et al. Gastric-and-intestinal mixed intestinal metaplasia is irreversible point with eradication of Helicobacter pylori[J]. Pathology,2016,6(2): 93-104.
[37]
Oh S, Kim N, Kwon JW,et al.Effect of Helicobacter pylori eradication and ABO genotype on gastric cancer development[J].Helicobacter,2016,21(6): 596-605.
[38]
Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori:a combined analysis of 12 case control studies nested within prospective cohorts[J].Gut,2001,49(3): 347-53.
[39]
Chiba T, Marusawa H, Ushijima T.Inflammation-associated cancer development in digestive organs:mechanisms and roles for genetic and epigenetic modulation[J].Gastroenterology,2012,143(3): 550-563.
[40]
Shin CM, Kim N, Lee HS,et al.Changes in aberrant DNA methylation after Helicobacter pylori eradication:a long-term follow-up study[J].Int J Cancer,2013,133(9): 2034-2042.
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