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中华胃肠内镜电子杂志 ›› 2022, Vol. 09 ›› Issue (01) : 36 -40. doi: 10.3877/cma.j.issn.2095-7157.2022.01.019

论著

卵巢癌结构域蛋白酶-6A在胃腺癌中的表达及临床意义
李京菊1, 刘德良2, 谭玉勇2,()   
  1. 1. 410000 长沙,长沙市三医院消化内科
    2. 中南大学湘雅二医院消化内科;中南大学消化病研究中心
  • 收稿日期:2021-08-20 出版日期:2022-02-15
  • 通信作者: 谭玉勇
  • 基金资助:
    国家自然科学基金青年基金(81902512)

The expression of OTUD-6A and its clinical significance in gastric adenocarcinoma

Jingju Li1, Deliang Liu2, Yuyong Tan2,()   

  1. 1. Department of Gastroenterology, the third hospital of Changsha
    2. Department of Gastroenterology, the second Xiangya hospital of Central South University; Research Center of Digestive Disease, Central South University, Changsha 410000, China
  • Received:2021-08-20 Published:2022-02-15
  • Corresponding author: Yuyong Tan
引用本文:

李京菊, 刘德良, 谭玉勇. 卵巢癌结构域蛋白酶-6A在胃腺癌中的表达及临床意义[J/OL]. 中华胃肠内镜电子杂志, 2022, 09(01): 36-40.

Jingju Li, Deliang Liu, Yuyong Tan. The expression of OTUD-6A and its clinical significance in gastric adenocarcinoma[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(01): 36-40.

目的

研究卵巢癌结构域蛋白酶-6A(OTUD6A)蛋白在胃腺癌组织中的表达水平,分析OTUD6A的表达与胃腺癌临床病理特征及预后的关系。

方法

选取2012年1月至2013年1月经中南大学湘雅二医院行胃腺癌根治术的40例患者纳入本研究,收集患者的癌组织、癌旁正常组织。采用免疫组织化学法检测肿瘤组织中OTUD6A的表达水平,采用卡方检验OTUD6A表达与胃腺癌临床病理特征及预后的关系,采用Kaplan-Meier法及Log-Rank检验分析其生存数据。

结果

OTUD6A在胃癌组织中的表达高于癌旁组织,其高表达与肿瘤浸润深度、分化程度、TNM分期有关(P<0.05)。

结论

胃腺癌组织中OTUD6A蛋白呈高表达,且与肿瘤浸润程度、分化程度及TNM相关。OTUD6A可能参与了胃腺癌的发生、发展。

Objective

To explore the expression of OTUD6A in gastric adenocarcinomatissues, as well as its association with clinicopathological characteristics and prognosis.

Methods

Forty patients who underwent gastric adenocarcinomaradical correction were enrolled in this study.Carcinoma tissues were obtained from these patients.The normal tissue 5 cm away from tumor margin was used. The expression of OTUD6A was detected by immunohistochemistry in gastric tissues.

Results

The expression of OTUD6A was higher in gastric adenocarcinoma tissues than that of in adjacent normal tissues, and high expression of OTUD6A was related to the depth of tumor invasion, degree of differentiation and TNM stage (P<0.05).

Conclusions

OTUD6A is highly expressed in gastric adenocarcinomatissues and was related to the local depth of tumor infiltration, degree of differentiation and TNM stage. OTUD6A may play a role in the occurrence, development and invasion of gastric adenocarcinoma.

图1 A:癌组织中OTUD6A呈高表达;B:癌旁组织中OTUD6A呈低表达注:A:胃癌组织(0);B:胃癌旁组织(0)
表1 OTUD6A在胃腺癌组织中的表达与临床病理特征的关系[n(%)]
图2 OTUD6A蛋白的表达与生存的关系
表2 胃癌预后与临床病理特征的单因素分析
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