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中华胃肠内镜电子杂志 ›› 2022, Vol. 09 ›› Issue (03) : 126 -129. doi: 10.3877/cma.j.issn.2095-7157.2022.03.002

论著

肠内营养支持干预在急性胰腺炎患者中的临床效果及对营养状态的影响研究
周怡1, 贺静1, 陈洪锁1, 李水霞2, 孟宪梅1,(), 党彤1   
  1. 1. 014030 包头,内蒙古科技大学包头医学院第二附属医院消化科
    2. 014030 包头,内蒙古科技大学包头医学院第二附属医院重症监护室
  • 收稿日期:2022-06-21 出版日期:2022-08-15
  • 通信作者: 孟宪梅
  • 基金资助:
    包头市医药卫生科技计划项目(wjwkj2020095)

The clinical effect of enteral nutrition support intervention in patients with actue pancreatitis and its influence on nutritional status

Yi Zhou1, Jing He1, Hongsuo Chen1, Shuixia Li2, Xianmei Meng1,(), Tong Dang1   

  1. 1. Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Baotou Medical College, Baotou 014030, China
    2. Intensive Care Unit, The Second Affiliated Hospital of Baotou Medical College, Baotou 014030, China
  • Received:2022-06-21 Published:2022-08-15
  • Corresponding author: Xianmei Meng
引用本文:

周怡, 贺静, 陈洪锁, 李水霞, 孟宪梅, 党彤. 肠内营养支持干预在急性胰腺炎患者中的临床效果及对营养状态的影响研究[J/OL]. 中华胃肠内镜电子杂志, 2022, 09(03): 126-129.

Yi Zhou, Jing He, Hongsuo Chen, Shuixia Li, Xianmei Meng, Tong Dang. The clinical effect of enteral nutrition support intervention in patients with actue pancreatitis and its influence on nutritional status[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(03): 126-129.

目的

研究肠内营养支持干预在急性胰腺炎患者中的临床效果及对营养状态的影响。

方法

选取2019年11月至2021年12月内蒙古科技大学包头医学院第二附属医院消化科治疗的83例急性胰腺炎(AP)患者作为研究对象,按随机数表法分为二组,对照组41例、观察组42例。对照组进行常规肠外营养支持干预,观察组给予肠内营养支持干预。比较两组患者的急性生理功能和慢性健康状况评分系统Ⅱ(APACHE Ⅱ)评分,比较两组患者血细胞因子水平和营养指标水平。

结果

干预2周后,观察组APACHE Ⅱ评分显著高于对照组(P<0.05);肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平均明显低于对照组(P<0.05);干预2周后,观察组患者血清前白蛋白(PA)、白蛋白(ALB)、转铁蛋白(TF)水平均显著高于对照组(P<0.05)。

结论

肠内营养支持干预能提高急性胰腺炎患者健康水平,降低血细胞炎症因子水平,改善患者营养状况,值得推广。

Objective

To study the clinical effect of enteral nutrition support intervention in patients with pancreatitis and its influence on nutritional status.

Methods

A total of 83 patients with acute pancreatitis who were treated in our hospital from November 2018 to December 2020 were selected as the research objects and were grouped according to the random number table method. Among them, 41 cases were in the control group and 42 cases in the observation group. The control group received routine parenteral nutrition support intervention, and the observation group received enteral nutrition support intervention. The acute physiological function and chronic health scoring system Ⅱ (APACHE Ⅱ) scores of the two groups were compared, and the blood cytokine levels and nutritional index levels of the two groups were compared.

Results

After 2 weeks of intervention, the APACHE Ⅱ score of the observation group was significantly higher than that of the control group (P<0.05); tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) level was significantly lower than that of the control group (P<0.05); after 2 weeks of intervention, the serum prealbumin (PA), albumin (ALB) and transferrin (TF) levels of the observation group were significantly higher than those of the control group (P<0.05).

Conclusion

Enteral nutrition support intervention can improve the health of patients with pancreatitis, reduce the level of blood cell inflammatory factors, and improve the nutritional status of patients. It is worthy of promotion.

表1 两组患者APACHEⅡ评分比较(分,±s)
表2 两组患者血清TNF-α、IL-6、IL-1β水平对比(pg/ml, ±s)
表3 两组患者营养指标比较(g/L, ±s)
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