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中华胃肠内镜电子杂志 ›› 2022, Vol. 09 ›› Issue (04) : 225 -228. doi: 10.3877/cma.j.issn.2095-7157.2022.04.006

综述

癌相关成纤维细胞在胃癌肿瘤微环境中的作用研究进展
朱新影1, 赵东强2,()   
  1. 1. 050061 石家庄,河北医科大学第二医院消化内科;050051 石家庄,河北医科大学第三医院消化内科
    2. 050061 石家庄,河北医科大学第二医院消化内科
  • 收稿日期:2022-09-08 出版日期:2022-11-15
  • 通信作者: 赵东强

The progress on the role of cancer-associated fibroblasts in the tumor microenvironment of gastric cancer

Xinying Zhu1, Dongqiang Zhao2,()   

  1. 1. Department of Gastroenterology, Second Hospital of Hebei Medical University, Shijiazhuang 050061, China; Department of Gastroenterology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
    2. Department of Gastroenterology, Second Hospital of Hebei Medical University, Shijiazhuang 050061, China
  • Received:2022-09-08 Published:2022-11-15
  • Corresponding author: Dongqiang Zhao
引用本文:

朱新影, 赵东强. 癌相关成纤维细胞在胃癌肿瘤微环境中的作用研究进展[J]. 中华胃肠内镜电子杂志, 2022, 09(04): 225-228.

Xinying Zhu, Dongqiang Zhao. The progress on the role of cancer-associated fibroblasts in the tumor microenvironment of gastric cancer[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(04): 225-228.

胃癌是消化系统最常见的恶性肿瘤之一,越来越多的证据表明,影响胃癌生物学行为的除了肿瘤细胞本身外,肿瘤细胞所处的局部生物环境,即胃癌肿瘤微环境,对胃癌的发生发展、转移、预后等也起着重要作用。肿瘤中活化的成纤维细胞称为癌相关成纤维细胞,它是胃癌肿瘤微环境中重要的基质成分,在胃癌的致病机制中起着至关重要的作用,本文对胃癌肿瘤微环境中癌相关成纤维细胞的作用研究进展作一综述。

Gastric cancer is one of the most common malignant tumors of the digestive system. More and more evidence has shown that the local biological environment of the tumor cells, namely the tumor microenvironment of gastric cancer, plays an important role in the occurrence, development, metastasis and prognosis of gastric cancer in addition to the tumor cells themselves. Activated fibroblasts in tumors are called cancer-associated fibroblasts, which are important stromal components in the tumor microenvironment of gastric cancer and play a crucial role in the pathogenesis of gastric cancer. Therefore, we systematically reviewed the research progress of cancer-associated fibroblasts in the tumor microenvironment of gastric cancer.

[1]
Sung HFerlay JSiegel RL,et al.Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin202171(3):209-249.
[2]
Siegel RLMiller KDJemal A.Cancer statistics 2020[J]. CA Cancer J Clin, 2020, 70(1): 7-30.
[3]
上海国家消化系疾病临床医学研究中心,国家消化道早癌防治中心联盟,中华医学会消化病学分会幽门螺杆菌学组,等.中国幽门螺杆菌根除与胃癌防控的专家共识意见(2019年,上海)[J].中华消化杂志201939(5):310-316.
[4]
Smyth EC, Nilsson M, Grabsch H, et al.Gastric cancer[J].Lancet2020396(10251): 635-648.
[5]
Smyth ECCervantes A.Addition of nivolumab to chemotherapy in patients with advanced gastric cancer:a relevant step ahead, but still many questions to answer[J].ESMO Open20205(6):e001107.
[6]
Zeng DLi MZhou R,et al.Tumor microenvironment characterization in gastric cancer identifies prognostic and immunotherapeutically relevant gene signatures[J].Cancer Immunol Res20197(5):737-750.
[7]
Kobayashi HEnomoto AWoods SL,et al.Cancer-associated fibroblasts in gastrointestinal cancer[J].Nat Rev Gastroenterol Hepatol201916(5):282- 295.
[8]
Thompson EDZahurak MMurphy A,et al.Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma[J].Gut201766(5):794-801.
[9]
Najafi MGoradel NHFarhood B,et al.Tumor microenvironment: interactions and therapy[J].J Cell Physiol2019234(5): 5700-5721.
[10]
Nazemi MRainero E.Cross-Talk Between the Tumor Microenvironment, Extracellular Matrix, and Cell Metabolism in Cancer[J].Front Oncol, 2020, 10:239.
[11]
Santana-Viera LIbba MLRotoli D,et al.Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts[J].Cancers (Basel), 202012(6):1365.
[12]
Kalluri RZeisberg M.Fibroblasts in cancer[J].Nat Rev Cancer, 2006, 6(5):392-401.
[13]
Sugimoto HMundel TMKieran MW,et al.Identification of fibroblast heterogeneity in the tumor microenvironment[J].Cancer Biol Ther2006, 5(12):1640-1646.
[14]
Kalluri R.The biology and function of fibroblasts in cancer[J].Nat Rev Cancer201616(9):582-598.
[15]
Alkasalias TMoyano-Galceran LArsenian-Henriksson M,et al. Fibroblasts in the Tumor Microenvironment:Shield or Spear?[J].Int J Mol Sci, 201819(5): 1532.
[16]
Xing FSaidou JWatabe K.Cancer associated fibroblasts (CAFs) in tumor microenvironment[J].Front Biosci (Landmark Ed)201015(1):166- 179.
[17]
Chen XSong E.Turning foes to friends: targeting cancer-associated fibroblasts[J].Nat Rev Drug Discov201918(2): 99-115.
[18]
Sahai EAstsaturov ICukierman E,et al.A framework for advancing our understanding of cancer-associated fibroblasts[J].Nat Rev Cancer, 2020, 20 (3):174-186.
[19]
Ma ZChen MYang X,et al.The Role of Cancer-associated Fibroblasts in Tumorigenesis of Gastric Cancer[J].Curr Pharm Des201824(28):3297 -3302.
[20]
Kim EKYoon SOJung WY,et al.Implications of NOVA1 suppression within the microenvironment of gastric cancer:association with immune cell dysregulation[J].Gastric Cancer201720(3):438-447.
[21]
郭嘉欣,徐远义.胃癌癌相关成纤维细胞研究进展[J].解放军医学杂志202146(3):306-310.
[22]
Harryvan TJVerdegaal EMEHardwick JCH,et al.Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies[J].J Clin Med20198(11):1989.
[23]
De Palma MBiziato DPetrova TV.Microenvironmental regulation of tumour angiogenesis[J]. Nat Rev Cancer, 201717(8):457-474.
[24]
Tang DGao JWang S,et al.Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression[J].Tumour Biol, 2016, 37(2): 1889-1899.
[25]
Ding XXi WJi J,et al.HGF derived from cancer associated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling[J].Oncol Rep201840(2):1185-1195.
[26]
Shen JZhai JYou Q,et al.Cancer-associated fibroblasts-derived VCAM1 induced by H.pylori infection facilitates tumor invasion in gastric cancer[J].Oncogene202039(14):2961-2974.
[27]
Wang XChe XLiu C,et al.Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1[J].Exp Cell Res2018368(2):184-193.
[28]
Yan YWang LFWang RF.Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer[J].World J Gastroenterol2015, 21(33):9717-9726.
[29]
Xu GZhang BYe J,et al.Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression[J].Int J Biol Sci201915(11): 2320-2329.
[30]
Barbazán JMatic Vignjevic D.Cancer associated fibroblasts: is the force the path to the dark side[J].Curr Opin Cell Biol201956:71-79.
[31]
Wu XTao PZhou Q,et al.IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway[J].Oncotarget2017, 8(13):20741-20750.
[32]
Fukui HZhang XSun C,et al.IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling[J].Br J Cancer2014111(4): 763-771.
[33]
Kurashige JMima KSawada G,et al.Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer[J]. Carcinogenesis, 201536(1):133-141.
[34]
Yang TSYang XHChen X,et al.MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN[J].FEBS Lett2014588(13):2162-2169.
[35]
Naito YSakamoto NOue N,et al.MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer [J].Cancer Sci2014105(2):228-235.
[36]
Kuroda KYashiro MSera T,et al.The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer[J].PLoS One201914(11): e0224727.
[37]
Wen XHe XJiao F,et al.Fibroblast activation protein-α-positive fibroblasts promote gastric cancer progression and resistance to immune checkpoint blockade[J]. Oncol Res201625(4):629-640.
[38]
Jiang GMXie WYWang HS,et al.Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2, 3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma[J]. Oncotarget20156(28):25932-25942.
[39]
Bae CAHam IHOh HJ,et al.Inhibiting the GAS6/AXL axis suppresses tumor progression by blocking the interaction between cancer-associated fibroblasts and cancer cells in gastric carcinoma[J]. Gastric Cancer, 2020, 23(5):824-836.
[40]
He YZhao XGao J,et al.Quantum dots-based immunofluorescent imaging of stromal fibroblasts Caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer[J]. Int J Mol Sci201213(11):13764-13780.
[41]
Li QZhu CCNi B,et al.Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts[J].EBioMedicine201949: 157-171.
[42]
Ma YZhu JChen S,et al.Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer[J].Cancer Cell Int201818:104.
[43]
Saito HFushida SHarada S,et al.Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast[J].Gastric Cancer2018, 21(1): 55-67.
[44]
Wang ZMa DWang C,et al.Triptonide inhibits the pathological functions of gastric cancer-associated fibroblasts[J].Biomed Pharmacother, 2017, 96(6):757-767.
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