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中华胃肠内镜电子杂志 ›› 2023, Vol. 10 ›› Issue (02) : 115 -120. doi: 10.3877/cma.j.issn.2095-7157.2023.02.007

论著

肥胖成人慢性腹泻患病率的系统评价和Meta分析
韩珂, 王祥耀, 茹楠, 牛晓彤, 向京元, 王妍, 高飞, 柴宁莉, 令狐恩强()   
  1. 100853 北京,解放军医学院;100853 北京,解放军总医院第一医学中心消化内科医学部
    100853 北京,解放军总医院第一医学中心消化内科医学部
  • 收稿日期:2023-03-13 出版日期:2023-05-15
  • 通信作者: 令狐恩强
  • 基金资助:
    国家重点研发计划(2020YFC2002705-2, 2022YFC2503601)

The prevalence of chronic diarrhea in obese adults: a systematic review with meta-analysis

Ke Han, Xiangyao Wang, Nan Ru, Xiaotong Niu, Jingyuan Xiang, Yan Wang, Fei Gao, Ningli Chai, Enqiang Linghu()   

  1. Medical School of Chinese PLA, Beijing 100853, China; Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
    Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  • Received:2023-03-13 Published:2023-05-15
  • Corresponding author: Enqiang Linghu
引用本文:

韩珂, 王祥耀, 茹楠, 牛晓彤, 向京元, 王妍, 高飞, 柴宁莉, 令狐恩强. 肥胖成人慢性腹泻患病率的系统评价和Meta分析[J]. 中华胃肠内镜电子杂志, 2023, 10(02): 115-120.

Ke Han, Xiangyao Wang, Nan Ru, Xiaotong Niu, Jingyuan Xiang, Yan Wang, Fei Gao, Ningli Chai, Enqiang Linghu. The prevalence of chronic diarrhea in obese adults: a systematic review with meta-analysis[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(02): 115-120.

目的

肥胖已成为全球严重的健康问题。多项研究表明,慢性腹泻在肥胖人群中较为常见。本研究对肥胖成人中慢性腹泻的患病率进行了系统评价和Meta分析。

方法

在PubMed、Embase和Web of Science文献数据库进行了系统检索,检索时间截止至2022年10月15日。本研究纳入了能够计算腹泻患病率的基于人群或肥胖患者的研究,由2名研究人员独立进行研究筛选,数据提取和质量评估。数据采用随机效应模型进行汇总。

结果

本研究共评估了8项研究,涉及19 701名受访者,其中11 820名为超重和肥胖个体。身体质量指数(body mass index, BMI)≥25 kg/m2的超重肥胖人群中,慢性腹泻的总体患病率为23.02%(95%CI: 17.47%, 28.57%)。肥胖组(BMI≥30 kg/m2)的腹泻患病率(23.79%,95%CI: 16.29%,31.29%)高于超重组(25 kg/m2≤BMI<30 kg/m2, 18.82%,95%CI: 13.02%,24.62%),但差异不具有统计学意义(P=0.30)。

结论

慢性腹泻在肥胖人群中相当常见,随着肥胖人数的增加,肥胖与慢性腹泻的共存值得更多关注。

Objective

Obesity has become a serious global health concern. A number of studies suggest that chronic diarrhea is frequent in obese people. We performed a systematic review and meta-analysis to assess the prevalence of chronic diarrhea in obese adults.

Methods

We systematically searched PubMed, Embase, and Web of Science for studies from inception through October 15, 2022.We included population-based or obese patient-based studies that could calculate the prevalence of diarrhea. Two researchers independently determined study eligibility, extracted data, and assessed quality.Data were pooled using a random effects model.

Results

Overall, 8 studies with 19, 701 respondents were assessed, including 11, 820 overweight and obese individuals.The pooled chronic diarrhea rate was 23.02% (95%CI: 17.47%, 28.57%) in people with a BMI≥ 25 kg/m2.The prevalence of diarrhea in the obese group (23.79%, 95%CI: 16.29%, 31.29%) was higher than that in the overweight group (18.82%, 95%CI: 13.02%, 24.62%), but it was not statistically significant (P=0.30).

Conclusions

Chronic diarrhea is quite common in obese populations.With the increasing number of obese people, and the coexistence of obesity and chronic diarrhea deserves extra attention.

图1 研究纳入和排除流程图
表1 入选研究基本信息和质量评估
图2 超重肥胖成人慢性腹泻患病率的森林图
图3 不同BMI亚组慢性腹泻患病率的森林图
图4 敏感性分析
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