切换至 "中华医学电子期刊资源库"

中华胃肠内镜电子杂志 ›› 2023, Vol. 10 ›› Issue (02) : 121 -124. doi: 10.3877/cma.j.issn.2095-7157.2023.02.008

综述

胃食管反流病与特发性肺纤维化关系的研究进展
吕昆明, 王沙沙, 万军, 令狐恩强()   
  1. 100853 北京,解放军总医院第二医学中心消化内科,国家老年医学研究中心
    100853 北京,解放军总医院第一医学中心消化内科医学部
  • 收稿日期:2023-04-25 出版日期:2023-05-15
  • 通信作者: 令狐恩强
  • 基金资助:
    国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2022003)

Research progress on the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis

Kunming Lv, Shasha Wang, Jun Wan, Enqiang Linghu()   

  1. Department of Gastroenterology, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
    Department of Gastroenterology and Hepatology, First Medical Center of The Chinese PLA General Hospital, Beijing, 100853, China
  • Received:2023-04-25 Published:2023-05-15
  • Corresponding author: Enqiang Linghu
引用本文:

吕昆明, 王沙沙, 万军, 令狐恩强. 胃食管反流病与特发性肺纤维化关系的研究进展[J/OL]. 中华胃肠内镜电子杂志, 2023, 10(02): 121-124.

Kunming Lv, Shasha Wang, Jun Wan, Enqiang Linghu. Research progress on the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(02): 121-124.

胃食管反流病(GERD)的临床表现除了反酸、烧心外,还可引起一系列食管外表现,其中,呼吸系统相关疾病发生率高。特发性肺纤维化(IPF)是一种以纤维化、炎症和肺结构破坏为特征的慢性间质性肺疾病,在其发病过程中,胃食管反流所致的长期慢性微量误吸具有重要的作用。本文将从GERD与特发性肺纤维化的相关性、抑酸及抗反流治疗在特发性肺纤维化治疗过程中的作用做一综述。

In addition to acid reflux and heartburn, the clinical manifestations of gastroesophageal reflux disease (GERD) can also include a series of extrA-esophageal complications, among which the incidence of respiratory system related diseases is high. Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis, inflammation and lung structure destruction. Long-term chronic microaspiration caused by gastroesophageal reflux plays an important role in the pathophysiological process of idiopathic pulmonary fibrosis. This article will review the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis, the role of acid suppression and anti-reflux therapy in the treatment of idiopathic pulmonary fibrosis.

[9]
Moran TJ.Experimental aspiration pneumonia. IV.Inflammatory and reparative changes produced by intratracheal injections of autologous gastric juice and hydrochloric acid[J].AMA Arch Pathol195560(2):122-129.
[10]
Mays EEDubois JJHamilton GB.Pulmonary fibrosis associated with tracheobronchial aspiration.A study of the frequency of hiatal hernia and gastroesophageal reflux in interstitial pulmonary fibrosis of obscure etiology[J]. Chest197669(4):512-515.
[11]
Linden PAGilbert RJYeap BY,et al.Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation[J].J Thorac Cardiovasc Surg2006, 131(2):438-446.
[12]
Raghu GYang STSpada C,et al.Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series[J].Chest2006129(3):794-800.
[13]
Lee JSRyu JHElicker BM,et al.Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis[J].Am J Respir Crit Care Med2011184(12):1390-1394.
[14]
Hershcovici TJha LKJohnson T,et al.Systematic review: the relationship between interstitial lung diseases and gastro-oesophageal reflux disease[J].Aliment Pharmacol Ther201134(11-12):1295-1305.
[15]
Raghu GFreudenberger TDYang S,et al.High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis[J].Eur Respir J2006, 27(1):136-142.
[16]
Tobin RWPope CEPellegrini CA,et al.Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis[J].Am J Respir Crit Care Med1998158(6):1804-1808.
[17]
Savarino ECarbone RMarabotto E,et al.Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients[J].Eur Respir J201342(5): 1322-1331.
[18]
Gao FHobson ARShang ZM,et al.The prevalence of gastro-esophageal reflux disease and esophageal dysmotility in Chinese patients with idiopathic pulmonary fibrosis[J].BMC Gastroenterol201515(1):1-8.
[19]
el-Serag HBSonnenberg A.Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans[J].Gastroenterology, 1997113(3):755-760.
[20]
Baqir MVasirreddy AVu AN,et al.Idiopathic pulmonary fibrosis and gastroesophageal reflux disease:A population-based,case-control study[J].Respir Med2021178:106309.
[21]
Gavini SBorges LFFinn RT,et al.Lung disease severity in idiopathic pulmonary fibrosis is more strongly associated with impedance measures of bolus reflux than pH parameters of acid reflux alone[J].Neurogastroenterol Motil201729(5):e13001.
[22]
Borges LFJagadeesan VGoldberg H,et al.Abnormal Bolus Reflux Is Associated With Poor Pulmonary Outcome in Patients With Idiopathic Pulmonary Fibrosis[J].J Neurogastroenterol Motil201824(3):395-402.
[23]
Lee JSSong JWWolters PJ,et al.Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis[J].Eur Respir J201239(2):352-358.
[24]
Appel JZLee SMHartwig MG,et al.Characterization of the innate immune response to chronic aspiration in a novel rodent model[J].Respir Res20078(1):87.
[1]
El-Serag HBSweet SWinchester CC,et al.Update on the epidemiology of gastro- oesophageal reflux disease: a systematic review[J].Gut201463(6):871-880.
[2]
Vakil Nvan Zanten SVKahrilas P,et al.The Montreal definition and classification of gastroesophageal reflux disease:a global evidence-based consensus[J].Am J Gastroenterol2006101(8):1900-1920.
[3]
Raghu GCollard HREgan JJ,et al.An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis:evidence-based guidelines for diagnosis and management[J].Am J Respir Crit Care Med2011183(6):788-824.
[4]
King TE JrPardo ASelman M.Idiopathic pulmonary fibrosis[J].Lancet2011, 378(9807):1949-1961.
[5]
Pleasants RTighe RM.Management of Idiopathic Pulmonary Fibrosis[J].Ann Pharmacother201953(12):1238-1248.
[6]
Sonnenberg A.Effects of environment and lifestyle on gastroesophageal reflux disease[J].Dig Dis201129(2):229-234.
[7]
Olson ALSwigris JJLezotte DC,et al.Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003[J].Am J Respir Crit Care Med, 2007176(3):277-284.
[8]
Marshall DCSalciccioli JDShea BS,et al.Trends in mortality from idiopathic pulmonary fibrosis in the European Union:an observational study of the WHO mortality database from 2001-2013[J].Eur Respir J201851(1): 1701603.
[25]
Downing TESporn TABollinger RR,et al.Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity[J].Exp Biol Med (Maywood)2008233(10):1202-1212.
[26]
Liu Y, Wang C, Chen H, et al. The profibrotic effects of chronic microaspiration of bile acids on lungs of rats at different stages[J].Int Immunopharmacol, 202084:106545.
[27]
Kreuter MWuyts WRenzoni E,et al.Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis:a pooled analysis[J].Lancet Respir Med20164(5): 381-389.
[28]
Tran TAssayag DErnst P,et al.Effectiveness of Proton Pump Inhibitors in Idiopathic Pulmonary Fibrosis:A Population-Based Cohort Study[J].Chest2021, 159(2):673-682.
[29]
Kilduff CECounter MJThomas GA,et al.Effect of acid suppression therapy on gastroesophageal reflux and cough in idiopathic pulmonary fibrosis: an intervention study[J].Cough201410(1): 4.
[30]
Bardhan KDStrugala VDettmar PW.Reflux revisited: advancing the role of pepsin[J]. Int J Otolaryngol20122012:646901.
[31]
Raghu GMorrow ECollins BF,et al.Laparoscopic anti-reflux surgery for idiopathic pulmonary fibrosis at a single centre[J].Eur Respir J201648(3):826-832.
[32]
Raghu GPellegrini CAYow E,et al.Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial[J].Lancet Respir Med20186(9):707-714.
[33]
郑研艳.抗反流黏膜切除术和贲门缩窄术治疗胃食管反流病的临床疗效对比 [D].郑州大学,2020.
[34]
Liu SChai NZhai Y,et al.New treatment method for refractory gastroesophageal reflux disease (GERD):C-BLART (clip band ligation anti-reflux therapy)-a short-term study[J].Surg Endosc202034(10):4516-4524.
[35]
胡海清,张海静,靳春露,等.经口内镜下贲门缩窄术治疗胃食管反流病的临床研究[J].中华消化内镜杂志201936 (8):563-567.
[36]
令狐恩强,王宇菲,王潇潇.内镜下贲门缩窄术治疗胃食管反流病的报道一例[J/CD]. 中华腔镜外科杂志(电子版)20136 (6):468-469.
[1] 白浪, 张雪玉, 白铁成, 贺爱军. 腹腔镜近端胃切除术中圆锥形重叠吻合成形术对Siewert Ⅱ型AEG患者胃食管反流、营养状态的影响研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 679-682.
[2] 李海云, 赵敏娴, 申英末, 杨慧琪. 胃底折叠术预防食管裂孔疝术后并发症的研究进展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 485-490.
[3] 玉素江·图荪托合提, 韩琦, 麦麦提艾力·麦麦提明, 黄旭东, 王浩, 克力木·阿不都热依木, 艾克拜尔·艾力. 腹腔镜袖状胃切除或联合食管裂孔疝修补术对肥胖症合并胃食管反流病的中期疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 501-506.
[4] 任传富, 杨志, 徐恩, 何梓芸, 罗板鑫, 陈新, 夏雪峰. 腹腔镜疝修补术联合胃底折叠术治疗食管裂孔疝合并胃食管反流病40 例临床分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 507-511.
[5] 杜晨阳, 王勇, 段鑫, 柯文杰, 石念, 武英翔, 罗文. 腹腔镜下食管裂孔疝修补术后吞咽困难的危险因素分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 523-527.
[6] 胡志伟, 吴继敏, 汪忠镐, 张美光. 胃食管反流病食管外症状抗反流手术适应证及术前评估[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 241-246.
[7] 王亚岚, 倪婧, 余世庆, 陶银花, 张荣. 尼达尼布抗纤维化治疗特发性肺纤维化的耐受性和疗效预测因素分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 750-755.
[8] 周璇, 谢莉, 邹娟. 尼达尼布对特发性肺纤维化肺功能、肺纤维化程度及PDGF、PGE2、TGF-β1的影响[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 368-372.
[9] 胡志伟, 吴继敏, 邓昌荣, 战秀岚, 纪涛, 王峰, 田书瑞, 陈冬, 张玉, 刘健男, 宋庆. 抗反流黏膜套扎治疗顽固性胃食管反流病[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(04): 227-233.
[10] 唐小久, 胡曼, 许必君, 肖亚. 肥胖合并胃食管反流病患者严重程度与其焦虑抑郁及营养状态的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 360-364.
[11] 王立辉, 杜海涛, 万军, 陈倩倩. 动态反流监测在食管-咽喉反流性疾病诊断中的临床应用[J/OL]. 中华胃肠内镜电子杂志, 2024, 11(04): 268-272.
[12] 张静, 白亦冰, 来要良, 刘永, 和媛媛, 苏敏. 不同体位对胃食管反流病患者食管高分辨率测压的影响[J/OL]. 中华胃食管反流病电子杂志, 2024, 11(03): 115-120.
[13] 张靖, 柏君, 陈玉盟, 张鹏, 侯芳芳, 王军芳, 孙静, 赵士博, 杨喆, 张玥, 张瑞芳, 朱宏斌. 抗反流黏膜消融术治疗胃食管反流病患者的临床疗效[J/OL]. 中华胃食管反流病电子杂志, 2024, 11(03): 121-125.
[14] 中国医师协会外科医师分会肥胖和代谢病外科专家工作组, 中国医师协会外科医师分会胃食管反流疾病诊疗外科专家工作组, 日本肥胖治疗学会, 韩国减重与代谢外科学会. 袖状胃切除术患者胃食管反流病诊治专家共识(2024版)[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(03): 145-162.
[15] 郭明杰, 周春起, 余佳慧, 李世红, 朱红梅, 刘雁军, 杨华武. 肥胖与胃食管反流病的关系及减重术后反流治疗研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(03): 184-192.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?