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中华胃肠内镜电子杂志 ›› 2026, Vol. 13 ›› Issue (01) : 25 -29. doi: 10.3877/cma.j.issn.2095-7157.2026.01.006

论著

利那洛肽联合低剂量复方聚乙二醇电解质用于便秘患者肠道准备的临床效果观察
赵振峰1, 刘璐1, 路璐1, 于晓欢1, 谢长访1, 侯丛然1, 陈玉杰1, 于占江1, 熊英1,2,3,()   
  1. 1071000 保定,保定市第一中心医院内镜诊疗中心
    2071000 保定,保定市胃肠动力相关疾病诊断重点实验室
    3071000 保定,保定市第一中心医院消化内科
  • 收稿日期:2025-11-15 出版日期:2026-02-15
  • 通信作者: 熊英
  • 基金资助:
    保定市科技计划项目(2241ZF059)

Clinical observation on the efficacy of linaclotide combined with lowdose compound polyethylene glycol electrolytes (PEG) for bowel preparation in constipated patients

Zhenfeng Zhao1, Lu Liu1, Lu Lu1, Xiaohuan Yu1, Changfang Xie1, Congran Hou1, Yujie Chen1, Zhanjiang Yu1, Ying Xiong1,2,3,()   

  1. 1Endoscopic Treatment Center, Baoding No.1 Central Hospital, Baoding 071000, China
    2Baoding Key Laboratory for the Diagnosis of Gastrointestinal Motility Disorders, Baoding 071000, China
    3Department of Gastroenterology, Baoding No.1 Central Hospital, Baoding 071000, China
  • Received:2025-11-15 Published:2026-02-15
  • Corresponding author: Ying Xiong
引用本文:

赵振峰, 刘璐, 路璐, 于晓欢, 谢长访, 侯丛然, 陈玉杰, 于占江, 熊英. 利那洛肽联合低剂量复方聚乙二醇电解质用于便秘患者肠道准备的临床效果观察[J/OL]. 中华胃肠内镜电子杂志, 2026, 13(01): 25-29.

Zhenfeng Zhao, Lu Liu, Lu Lu, Xiaohuan Yu, Changfang Xie, Congran Hou, Yujie Chen, Zhanjiang Yu, Ying Xiong. Clinical observation on the efficacy of linaclotide combined with lowdose compound polyethylene glycol electrolytes (PEG) for bowel preparation in constipated patients[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2026, 13(01): 25-29.

目的

探讨利那洛肽联合低剂量复方聚乙二醇电解质散(PEG)在便秘患者肠道准备中的安全性和可行性。

方法

选取2022年3月到2023年10月就诊于保定市第一中心医院内镜诊疗中心行结肠镜检查的300例患者,采用随机数字表将受试者分为两组。A组(对照组)患者服用4L-PEG行肠道准备,B组(实验组)患者服用870 μg利那洛肽联合3L-PEG行肠道准备,比较两组之间波士顿肠道准备评分(右半结肠、横结肠、左半结肠和总体肠道评分)及患者不良反应发生率。

结果

B组的右半结肠、横结肠、左半结肠及总体肠道评分均高于A组,差异具有统计学意义(P<0.05),B组患者的不良反应率明显低于A组,差异具有统计学意义(P<0.05)。

结论

870 μg利那洛肽联合3L-PEG作为肠道准备方案的肠道清洁度优于传统4L-PEG方案,且不良反应发生率较低。

Objective

To investigate the safety and feasibility of linaclotide combined with low-dose Compound Polyethylene Glycol Electrolytes Powder (PEG) for bowel preparation in constipated patients.

Methods

A total of 300 patients scheduled for colonoscopy at the Endoscopy Center of Baoding First Central Hospital from March 2022 to October 2023 were enrolled.Participants were randomly divided into two groups using a random number table.Group A as control group, received 4L-PEG for bowel preparation.Group B as Experimental group, received 870μg linaclotide combined with 3L-PEG for bowel preparation.Bowel cleanliness was evaluated using the Boston Bowel Preparation Scale (BBPS) scores (right colon, mid-colon, distal colon, and total score). Adverse event rates were compared between groups.

Results

Group B demonstrated significantly higher BBPS scores in the right colon, mid-colon, distal colon, and total score compared to Group A (P<0.05). Additionally, the adverse event rate in Group B was significantly lower than that in Group A, with the difference being statistically significant (P<0.05).

Conclusion

The bowel preparation protocol combining 870 μg linaclotide with 3L-PEG provides superior bowel cleanliness to the conventional 4L-PEG regimen, with a lower incidence of adverse events.

表1 两组患者一般资料的比较[例(%),±s]
表2 两组患者BBPS的比较(±s)
表3 两组患者不良反应的比较[例(%)]
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