Abstract:
Objective To compare the clinical efficacy of peroral endoscopic cardial constriction (PECC) and double-dose esomeprazole on the treatment of refractory gastroesophageal reflux disease (rGERD).
Methods A prospective randomized controlled study was conducted on the data of 64 patients with rGERD at Baoding No.1 Central Hospital from January 2019 to May 2020. According to the principle of randomized control trial, patients were divided into PECC group and esomeprazole group, with 32 cases in each group.The former under went PECC and the latter taken oral esomeprazole and mosapride citrate. The reflux symptoms, quality of life scores and satisfaction between the two groups were compared after 3 and 6 months.
Results After 3 and 6 months follow-up reflux disease questionnaire (RDQ), reflux symptom index (RSI), health related quality of life scale gastroesophageal reflux disease (GERD-HRQL) scores in the PECC group were significantly lower than those in the esomeprazole group (P<0.01). After 6 months follow-up, the satisfaction rate of PECC group and esomeprazole group was 87.5% (28/32) and 40.63% (13/32), respectively.There was significant difference in satisfaction between the two groups (P<0.05), and no obvious serious complications in the PECC group.
Conclusion In terms of short-term efficacy, PECC is more advantageous than double-dose esomeprazole in improving reflux symptoms and enhancing quality of life in patients with rGERD. It can alleviate the symptoms of rGERD throat reflux, and significantly reduce rGERD acid reflux、heartburn and other esophageal reflux symptoms. It can distinctly improve the quality of life and can be used as a treatment option for rGERD.
Key words:
Peroral endoscopic cardial constriction,
Esomeprazole,
Refractory gastroesophageal reflux disease,
Relieve symptoms,
Satisfaction
Huixia Cao, Ying Xiong, Jing Han, Jinzhuo Zhang, Yichao Yang, Yaling Wang, Chongyang Yang. Comparison of peroral endoscopic cardial constriction and double-dose esomeprazole on clinical efficacy of refractory gastroesophageal reflux disease[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2021, 08(04): 171-175.