Objective To develop expert consensus on the environment and layout of digestive endoscopy center.The overall layout, area partition and the configuration of medical equipment, protective equipment and fire facilities were designed according to the principle of "definite function, matched quantity, safe specification, reasonable layout". To avoid the risk of infection control and improve operation safety and patient satisfaction.

A compilation team was established to conduct article search on several databases such as China National Knowledge Infrastructure (CNKI) according to relevant domestic and foreign guidelines and consensus to screen and grade evidence.The preliminary draft of the consensus was completed, and was discussed through two rounds of expert demonstration meetings to carry out adjustment and modification before the consensus was developed.

The consensus suggest the digestive endoscopy center consist six functional area: appointment waiting area, diagnosis and treatment area, cleaning and disinfection area, resuscitation area, office and public living area and medical auxiliary area. The contents cover the layout and environmental requirements and standards of the relevant functional areas of the digestive endoscopy center, as well as how to do a good job in the relevant medical care of the digestive endoscopy center.

The consensus item is simple, clear and easy to implement. The new content can complement and improve the existing norms and standards to a certain extent. It can provide reference standards for new, rebuilt and expanded endoscopic diagnosis and treatment centers and guide clinical practice.

To investigate the features of CT and endoscopy in Low-grade appendiceal mucinous neoplasms confined to the appendix (LAMNs).

Fifteen cases with histologically proven LAMNs confined to the appendix were included in this study from January 2014 to December 2019. Clinical data, and the characteristics of CT and endoscopy examinations were retrospectively analyzed.

All patients had received CT and endoscopy examinations before surgery. In CT images, the median size is 5.8 (2.5-11.0) cm. All tumors had well-circumscribed margins. In enhanced CT images, early mild ring mural enhancement of the cystic wall was observed. The endoscopy examinations showed a round mass protruding from the appendiceal orifice, with normal overlying mucosa in most cases. Eight cases received EUS examinations, which showed an "onion skin" sign. All cases were treated with surgery, including 7 cases undergoing appendectomy and 8 receiving right hemicolectomy.

Although preoperative diagnosis of LAMNs confined to the appendix remains challenging, LAMNs should be considered when the "onion skin" sign is detected on EUS.

In recent years, many hospitals both home and abroad have performed a series of surgeries under the concept of super minimally invasive surgery (SMIS), which highlights the advantages of SMIS.However, there is no expert consensus on wound pretreatment and antibiotic application for this type of surgery.This consensus aims to discuss the issues of wound pretreatment and antibiotic application in digestive endoscopic SMIS based on the best available scientific evidence.

Experts were recruited from the Super Minimally Invasive Surgery Group, ERCP Group, Ultrasound Endoscopy Group, Endoscopic Surgery Group, Early Gastrointestinal Cancer Collaborative Group, Esophageal Disease Collaborative Group, Gastric Disease Collaborative Group, Pancreatic Disease Collaborative Group and Endoscopic Tunneling Technology Group of Chinese Society of Digestive Endoscopology to form the expert group and a clinical question list was created.Each question was assigned to experts to form the statements which were then discussed and revised to reach agreement in 3 online and offline meetings between November 2022 and April 2023. Finally, the full statement collection was sent to all expert group members to grade the evidence, classify the statements, and vote on the strength of the statements.

Sixteen statements on surgical wound pretreatment and antibiotic application in four surgical channels of digestive endoscopic SMIS were formulated, including 5 statements on surgical wound pretreatment and 11 statements on antibiotic application.

The consensus on wound pretreatment and antibiotic application for digestive endoscopic SMIS is the first published among all societies. This consensus recommends that in the clinical practice of SMIS, endoscopists should fully consider the characteristics of different surgical channels, choose different wound pretreatment and antibiotic application methods, formulate isolation measures, strictly disinfect the endoscope, and use disposable sterile instruments to minimize the incidence of infection. In addition, multi-cavity channels involve the field of minimally invasive surgery, so surgical procedures should be followed at the same time.

The mode of organ resection and reconstruction that has been used to treat digestive tumors can cure the disease. However, it involves the surgical resection of critical structures (such as the cardia, pylorus, and anus) and gastrointestinal reconstruction, which alter the physiological anatomy of the digestive system. These changes often lead to numerous postoperative complications and severely affect the patient's quality of life (e.g., refractory gastroesophageal reflux following proximal gastrectomy, dumping syndrome after subtotal gastrectomy, loss of anal function after low rectal surgery). For the defect of this mode, in 2016, professor Linghu Enqiang proposed the new mode that was "curing the disease and restoring normal function", we named this new mode: Super Minimally Invasive Surgery (SMIS)^[1]. To accomplish various types of SMIS, four operative channels were developed: the natural cavity channel, the tunnel channel, the puncture channel, and the multi-cavity channel. SMIS, with its advantages of minimal trauma and organ function preservation, has been recognized by authoritative domestic and international organizations and has developed rapidly. Based on its clinical value and the need for wider application, there is an urgent need to establish standardized guidelines to guide practice. This guideline was developed by leading organizations such as the SMIS Committee of World Endoscopy Organization and Chinese Society of Digestive Endoscopy (CSDE), in collaboration with multidisciplinary experts from gastroenterology, surgery, and pathology. Systematic searches were conducted in nine major databases, including PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for both Chinese and English literature published before 2025.Evidence from randomized controlled trials, observational studies, and case series was included, with the quality of evidence and recommendation strength evaluated using the GRADE system (high-level evidence: randomized controlled trials; low-level evidence: observational studies). The recommendations were refined through multiple rounds of expert discussion and voting and reported according to AGREE II and RIGHT standards. The guideline has been registered on the International Practice Guidelines Platform (PREPARE, registration number PREPARE-2024CN1183). This consensus addresses 15 issues related to SMIS treatment for esophageal cancer, gastric cancer, colorectal cancer, their corresponding precancerous lesions, and precancerous lesions of the duodenal papilla. It provides corresponding recommendations in three main areas: (1) Definitions and principles: SMIS should meet ten core criteria, including organ preservation, complete resection(R0), and sterile procedures. It also standardizes naming conventions (e.g., "Super minimally invasive non-full-thickness resection of lower esophageal squamous carcinoma via the oral cavity" ). (2) Surgical recommendations: Esophageal cancer: For early and precancerous lesions, SMIS of non-full-thickness resection is preferred. For circumferential involvement ≥1/2, SMIS of tunnel approach for non-full-thickness resection is recommended. If the wound circumference is ≥75%, the use of corticosteroids or stents to prevent stenosis is advised. Gastric cancer: For T1a-T1b stage and precancerous lesions, SMIS non-full-thickness or full-thickness resection is preferred, with individualized plans based on the risk of lymph node metastasis (LNM). Colorectal cancer: SMIS of non-full-thickness or full-thickness resection is recommended as the first-line treatment for T1a-T1b stage and precancerous lesions. For locally advanced rectal cancer that achieves clinical remission after neoadjuvant therapy, SMIS of full-thickness resection can be considered to assess pathological remission. Duodenal papilla precancerous lesions: SMIS resection via the oral cavity is preferred. Postoperatively, whether to add pancreaticoduodenectomy and follow-up strategies should be determined based on pathology.(3) Postoperative management: A SMIS treatment cure evaluation system for early gastric cancer was established, divided into SMIS-Cure A (cured), SMIS-Cure B (clinically cured), and SMIS-Cure C (surgical reassessment), which guides follow-up. For colorectal cancer or precancerous lesions, R0 resection is the standard for cure, and follow-up plans are developed according to risk stratification. This guideline systematically integrates the evidence from SMIS in the treatment of gastrointestinal tumors with expert consensus, establishing a standardized pathway centered on organ function preservation. It shifts the treatment model from "cure first" to "cure-function balance". Its application is expected to reduce overtreatment, improve the patient′s quality of life, and provide a framework for future technological iterations and the expansion of indications. It should be continuously optimized with multi-center clinical data and long-term follow-up results to achieve more precise, individualized treatment.

Hereditary pancreatitis is a type of chronic pancreatitis with a high risk of cancer and one of the major causes of pancreatitis in children. This article reviews the recent research progress of hereditary pancreatitis, including diagnosis, pathogenic genes, pathogenesis, and treatment, and aims to provide new reference information for the diagnosis and treatment of genetic pancreatitis and basic research.