Chinese expert consensus on endoscopic cyanoacrylate injection for gastrointestinal varices in patients with portal hypertention induced by liver cirrhosis

doi:10.3877/cma.j.issn.2095-7157.2022.04.002

Abstract

Abstract:

Liver cirrhosis and portal hypertension may cause gastrointestinal varices, endoscopic cyanoacrylate injection plays an important role in the treatment of gastrointestinal varices. However, no specific consensus on endoscopic cyanoacrylate injection has been published. In 2022, a multidisciplinary team all over the country under the leadership of Endoscopic Diagnosis and Treatment of Esophagogastric Varices Group of Chinese Society of Digestive Endoscopology conducted a comprehensive discussion and proposed the consensus, to serve as a tool for Chinese clinicians to standardize endoscopic cyanoacrylate injection treatment for gastrointestinal varices. There are eleven parts in the consensus, with a total of 22 recommendations, including grade and diagnosis of gastrointestinal varices, indication of endoscopic cyanoacrylate injection, etc.

Key words: Liver cirrhosis, Portal hypertension, Gastrointestinal varices, Endoscopic cyanoacrylate injection, Guideline

Endoscopic Diagnosis and Treatment of Esophagogastric Varices Group, Chinese Society of Digestive Endoscopology, Beijing 100710, China. Chinese expert consensus on endoscopic cyanoacrylate injection for gastrointestinal varices in patients with portal hypertention induced by liver cirrhosis[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(04): 193-206.

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References 139

[32]	Zhu H，Shi B，Upadhyaya M，et al.Therapeutic endoscopy of localized gastric varices: pretherapy screening and posttreatment evaluation with MDCT portography [J]．Abdom Imaging，2010，35(1)：15-22.
[33]	李保灿，刘清欣，黄文启，等．一站式完成肝脏磁共振动态增强并血管成像对食管胃静脉曲张的诊断价值[J]．中国基层医药，2013，20(8)：1159-1161.
[34]	Shin SU，Lee JM，Yu MH，et al.Prediction of esophageal varices in patients with cirrhosis: usefulness of three-dimensional MR elastography with echo-planar imaging technique[J]．Radiology，2014，272(1)：143-153.
[35]	Mattos ÂZ，Schacher FC，John Neto G，et al.Screening for esophageal varices in cirrhotic patients - Non-invasive methods[J]．Ann Hepatol，2019，18(5)：673-678.
[36]	Sami SS，Harman D，Ragunath K，et al.Non-invasive tests for the detection of oesophageal varices in compensated cirrhosis: systematic review and meta-analysis[J]. United European Gastroenterol J, 2018，6(6)：806-818.
[37]	Butler JR，Eckert GJ，Zyromski NJ，et al.Natural history of pancreatitis-induced splenic vein thrombosis：a systematic review and meta-analysis of its incidence and rate of gastrointestinal bleeding[J]．HPB (Oxford), 2011，13(12)：839-845.
[38]	ASGE Technology Committee, Bhat YM，Banerjee S，et al.Tissue adhesives: cyanoacrylate glue and fibrin sealant[J]．Gastrointest Endosc，2013，78(2)：209-215.
[39]	Datta D，Vlavianos P，Alisa A，et al.Use of fibrin glue (beriplast) in the management of bleeding gastric varices[J]．Endoscopy，2003，35(8)：675-678.
[40]	Lo GH，Lin CW，Tai CM，et al.A prospective, randomized trial of thrombin versus cyanoacrylate injection in the control of acute gastric variceal hemorrhage[J]. Endoscopy，2020，52(7)：548-555.
[41]	Soehendra N，Nam VC，Grimm H，et al.Endoscopic obliteration of large esophagogastric varices with bucrylate[J]．Endoscopy，1986，18(1)：25-26.
[42]	Soehendra N，Grimm H，Nam VC，et al.N-butyl-2-cyanoacrylate: a supplement to endoscopic sclerotherapy[J]．Endoscopy，1987，19(6)：221-224.
[43]	程留芳，令狐恩强，王志强，等．孤立性胃底静脉曲张病因分析与治疗方法[J]. 中华消化杂志，2000，20(1)：42-44.
[44]	Kaplan JA，Bitner RL，Dripps RD.Hypoxia, hyperdynamic circulation, and the hazards of general anesthesia in patients with hepatic cirrhosis[J]．Anesthesiology, 1971，35(4)：427-431.
[45]	于琳，尚国臣，陈丽娜，等．气管插管与非气管插管静脉复合麻醉在食管胃静脉曲张内镜治疗中的对比分析[J]．世界华人消化杂志，2019，27(5)：299-304.
[46]	Weil D，Cervoni JP，Fares N，et al.Club Francophone pour l’Etude de l’Hypertension Portale (CFEHTP). Management of gastric varices：a French national survey[J]．Eur J Gastroenterol Hepatol, 2016，28(5)：576-581.
[47]	Rice JP，Lubner M，Taylor A，et al.CT portography with gastric variceal volume measurements in the evaluation of endoscopic therapeutic efficacy of tissue adhesive injection into gastric varices: a pilot study[J]．Dig Dis Sci，2011，56(8)：2466-2472.
[1]	Bosch J，Iwakiri Y．The portal hypertension syndrome：etiology，classification, relevance, and animal models[J]．Hepatol Int，2018，12(Suppl 1)：1-10.
[2]	Khanna R，Sarin SK.Non-cirrhotic portal hypertension diagnosis and management [J]．J Hepatol，2014，60(2)：421-441.
[3]	de Franchis R，Baveno VI Faculty.Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension[J]．J Hepatol，2015，63(3)：743-752.
[4]	中国门静脉高压诊断与监测研究组(CHESS)，中华医学会消化病学分会微创介入协作组，中国医师协会介入医师分会急诊介入专委会，等．中国肝静脉压力梯度临床应用专家共识(2018版)[J]．中华肝脏病杂志，2018，26(11)：801-812.
[5]	Al-Khazraji A，Curry MP.The current knowledge about the therapeutic use of endoscopic sclerotherapy and endoscopic tissue adhesives in variceal bleeding[J]. Expert Rev Gastroenterol Hepatol，2019，13(9)：893-897.
[6]	中华医学会消化病学分会，中华医学会肝病学分会，中华医学会内镜学分会. 肝硬化门静脉高压食管胃静脉曲张出血的防治共识[J]．中华肝脏病杂志，2008，16(8)：564-570.
[7]	中华医学会消化内镜学分会食管胃静脉曲张学组．消化道静脉曲张及出血的内镜诊断和治疗规范试行方案(2009年)[J]．中华消化内镜杂志，2010，27(1)：1-4.
[8]	中华医学会肝病学分会，中华医学会消化病学分会，中华医学会消化内镜学分会．肝硬化门静脉高压食管胃静脉曲张出血的防治指南[J]．中华内科杂志，2016，55(1)：57-72.
[9]	中华医学会外科学分会脾及门静脉高压外科学组．肝硬化门静脉高压症食管、胃底静脉曲张破裂出血诊治专家共识(2019版)[J]．中华外科杂志，2019，57 (12): 885-892.
[10]	Tripathi D，Stanley AJ，Hayes PC，et al.Clinical Services and Standards Committee of the British Society of Gastroenterology. U．K. guidelines on the management of variceal haemorrhage in cirrhotic patients[J]．Gut，2015，64(11)：1680-1704.
[11]	Garcia-Tsao G，Abraldes JG，Berzigotti A，et al.Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases[J]．Hepatology, 2017，65(1): 310-335.
[12]	European Association for the Study of the Liver.EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis[J]. J Hepatol, 2018，69(2)：406-460.
[13]	de Franchis R，Bosch J，Garcia-Tsao G，et al.Baveno VII Faculty. Baveno VII - Renewing consensus in portal hypertension[J]．J Hepatol，2022，76(4)：959-974.
[14]	Henry Z，Patel K，Patton H，et al.AGA Clinical Practice Update on Management of Bleeding Gastric Varices：Expert Review[J]．Clin Gastroenterol Hepatol，2021，19(6): 1098-1107，e1.
[15]	Sarin SK，Kumar A．Gastric varices: profile, classification, and management[J]. Am J Gastroenterol, 1989，84(10)：1244-1249.
[16]	Hwang JH，Shergill AK，Acosta RD，et al.American Society for Gastrointestinal Endoscopy. The role of endoscopy in the management of variceal hemorrhage[J]. Gastrointest Endosc, 2014，80(2)：221-227.
[48]	Sarin SK，Lahoti D，Saxena SP，et al.Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients[J]. Hepatology，1992，16(6)：1343-1349.
[49]	Kim T，Shijo H，Kokawa H，et al.Risk factors for hemorrhage from gastric fundal varices[J]．Hepatology，1997，25(2)：307-312.
[50]	Mishra SR，Sharma BC，Kumar A，et al.Primary prophylaxis of gastric variceal bleeding comparing cyanoacrylate injection and beta-blockers：a randomized controlled trial[J]．J Hepatol，2011，54(6)：1161-1167.
[51]	Chandra S，Holm A，El Abiad RG，et al.Endoscopic Cyanoacrylate Glue Injection in Management of Gastric Variceal Bleeding：US Tertiary Care Center Experience[J]. J Clin Exp Hepatol，2018，8(2)：181-187.
[52]	Paik CN，Kim SW，Lee IS，et al.The therapeutic effect of cyanoacrylate on gastric variceal bleeding and factors related to clinical outcome[J]．J Clin Gastroenterol, 200，42(8)：916-922.
[53]	Iwase H，Maeda O，Shimada M，et al.Endoscopic ablation with cyanoacrylate glue for isolated gastric variceal bleeding[J]．Gastrointest Endosc，2001，53(6)：585-592.
[54]	Dhiman RK，Chawla Y，Taneja S，et al.Endoscopic sclerotherapy of gastric variceal bleeding with N-butyl-2-cyanoacrylate[J]．J Clin Gastroenterol, 2002，35(3): 222-227.
[55]	Marques P，Maluf-Filho F，Kumar A，et al.Long-term outcomes of acute gastric variceal bleeding in 48 patients following treatment with cyanoacrylate[J]．Dig Dis Sci, 2008，53(2)：544-550.
[56]	Al-Ali J，Pawlowska M，Coss A，et al.Endoscopic management of gastric variceal bleeding with cyanoacrylate glue injection: safety and efficacy in a Canadian population[J]．Can J Gastroenterol，2010，24(10)：593-596.
[57]	Qiao W，Ren Y，Bai Y，et al.Cyanoacrylate Injection Versus Band Ligation in the Endoscopic Management of Acute Gastric Variceal Bleeding：Meta-Analysis of Randomized，Controlled Studies Based on the PRISMA Statement[J]．Medicine (Baltimore), 2015，94(41)：e1725.
[58]	Mahadeva S，Bellamy MC，Kessel D，et al.Cost-effectiveness of N-butyl-2- cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding[J]．Am J Gastroenterol，2003，98(12)：2688-2693.
[59]	Shin JH.Treatment of patients with gastric variceal hemorrhage: endoscopic N-butyl-2-cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration[J]．J Gastroenterol Hepatol，2009，24(3)：372-378.
[60]	Stein DJ，Salinas C，Sabri S，et al.Balloon Retrograde Transvenous Obliteration Versus Endoscopic Cyanoacrylate in Bleeding Gastric Varices：Comparison of Rebleeding and Mortality with Extended Follow-up[J]．J Vasc Interv Radiol, 2019，30(2)：187-194.
[61]	Mishra SR，Chander Sharma B，Kumar A，et al.Endoscopic cyanoacrylate injection versus beta-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial[J]．Gut，2010，59(6)：729-735.
[62]	Lo GH，Liang HL，Chen WC，et al.A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding[J]．Endoscopy，2007，39(8)：679-685.
[63]	Luo X，Xiang T，Wu J，et al.Endoscopic Cyanoacrylate Injection Versus Balloon-Occluded Retrograde Transvenous Obliteration for Prevention of Gastric Variceal Bleeding：A Randomized Controlled Trial[J]. Hepatology, 2021，74(4)：2074-2084.
[17]	Horsley-Silva JL，Vargas HE.Gastrointestinal endoscopy in the cirrhotic patient[J]．Expert Rev Gastroenterol Hepatol，2015，9(7)：1005-1013.
[18]	Sakr MA，Ebada HE，Abdelkader S，et al.Outcome of Colonoscopic Screening in Potential Liver Transplant Candidates[J]．Transplant Proc，2020，52(1)：227-232.
[19]	McCarty TR，Afinogenova Y，Njei B．Use of Wireless Capsule Endoscopy for the Diagnosis and Grading of Esophageal Varices in Patients With Portal Hypertension: A Systematic Review and Meta-Analysis[J]．J Clin Gastroenterol，2017，51(2)：174- 182.
[20]	Krok KL，Wagennar RR，Kantsevoy SV，et al.Esophageal capsule endoscopy is not the optimal technique to determine the need for primary prophylaxis in patients with cirrhosis[J]．Arch Med Sci, 2016，12(2)：365-371.
[21]	中华医学会消化内镜学分会．中国胶囊内镜临床应用指南[J]．中华消化内镜杂志，2014，31(10)：549-558.
[22]	Cardey J，Le Gall C，Michaud L，et al.Screening of esophageal varices in children using esophageal capsule endoscopy: a multicenter prospective study[J]．Endoscopy, 2019，51(1)：10-17.
[23]	Dabos KJ，Yung DE，Bartzis L，et al.Small bowel capsule endoscopy and portal hypertensive enteropathy in cirrhotic patients: results from a tertiary referral centre[J]. Ann Hepatol，2016，15(3)：394-401.
[24]	Seiji K，Akinobu T，Masaya I，et al.Safety and Efficacy of Small Bowel Examination by Capsule Endoscopy for Patients before Liver Transplantation[J]. Biomed Res Int，2017，2017：8193821.
[25]	帖广玄，张瑜，左晨燕，等．超声胃镜在食管胃底静脉曲张中的应用进展[J]．临床消化病杂志，2018，30(1)：62-65.
[26]	Hammoud GM, Ibdah JA. Utility of endoscopic ultrasound in patients with portal hypertension[J]. World J Gastroenterol, 2014，20(39)：14230-14236.
[27]	Li Y，Li L，Weng HL，et al.Computed tomography vs liver stiffness measurement and magnetic resonance imaging in evaluating esophageal varices in cirrhotic patients: A systematic review and meta-analysis[J]．World J Gastroenterol，2020，26(18)：2247-2267.
[28]	Tseng YJ，Zeng XQ，Chen J，et al.Computed tomography in evaluating gastroesophageal varices in patients with portal hypertension: A meta-analysis[J]. Dig Liver Dis, 2016，48(7)：695-702.
[29]	胡海东，张见增. 216例肝硬化门静脉高压症患者CT血管成像门静脉侧支血管表现研究[J]. 实用肝脏病杂志，2016，19(1)：73-76.
[30]	吴琼，吴兴旺，许建明，等. CT血管造影成像对门脉高压症胃底静脉曲张分流状态的评估价值[J]. 世界华人消化杂志，2015，23(14)：2268-2273.
[31]	刘桂勤，华静，沈加林. CT门静脉血管成像预测肝硬化门静脉高压食管胃底静脉曲张破裂出血价值[J]．中华实用诊断与治疗杂志，2015，29(4)：396-398.
[64]	Ljubicic N，Biscanin A，Nikolic M，et al.A randomized-controlled trial of endoscopic treatment of acute esophageal variceal hemorrhage: N-butyl-2- cyanoacrylate injection vs. variceal ligation[J]．Hepatogastroenterology, 2011，58(106): 438-443.
[65]	Almadi MA，Almessabi A，Wong P，et al.Ectopic varices[J]. Gastrointest Endosc, 2011，74(2)：380-388.
[66]	Watanabe N, Toyonaga A, Kojima S, et al. Current status of ectopic varices in Japan: Results of a survey by the Japan Society for Portal Hypertension[J]. Hepatol Res, 2010，40(8)：763-776.
[67]	Yipeng W，Anjiang W，Bimin L，et al.Clinical characteristics and efficacy of endoscopic treatment of gastrointestinal ectopic varices：A single-center study[J]. Saudi J Gastroenterol，2021，27(1)：35-43.
[68]	Mora-Soler A，Velasco-Guardado A，Acosta-Materán R，et al.Endoscopic treatment of duodenal varices with cyanoacrylate[J]．Rev Esp Enferm Dig, 2013，105 (10)：629-632.
[69]	Liu Y，Yang J，Wang J，et al.Clinical characteristics and endoscopic treatment with cyanoacrylate injection in patients with duodenal varices[J]. Scand J Gastroenterol, 2009，44(8)：1012-1016.
[70]	李京菊，谭玉勇，刘德良．内镜治疗十二指肠异位静脉曲张一例[J]．中华消化内镜杂志，2020，37(3)：211-212.
[71]	万义鹏，刘聪，朱萱．十二指肠静脉曲张的诊治进展[J]．中华消化内镜杂志，2021，38(2)：163-166.
[72]	Ryu SH，Moon JS，Kim I，et al.Endoscopic injection sclerotherapy with N-butyl- 2-cyanoacrylate in a patient with massive rectal variceal bleeding：a case report[J]. Gastrointest Endosc，2005，62(4)：632-635.
[73]	Ozaka S，Gotoh Y，Honda S，et al.Rectal varix treated with endoscopic cyanoacrylate injection therapy[J]．Clin J Gastroenterol，2021，14(3)：791-795.
[74]	Chong VH，Tan KK，Sharif F．Successful treatment of parastomal varices bleeding with percutaneous N-butyl-2-cyanoacrylate glue injection[J]．Surg Laparosc Endosc Percutan Tech，2008，18(5)：520-522.
[75]	Hsu YC，Yen HH，Chen YY，et al.Successful endoscopic sclerotherapy for cholecystojejunostomy variceal bleeding in a patient with pancreatic head cancer[J]. World J Gastroenterol, 2010，16(1)：123-125.
[76]	Kitagawa S，Sato T，Kimura M．Endoscopic sclerotherapy with a high concentration of n-butyl-2-cyanoacrylate for anastomotic varices after choledochojejunostomy[J]. Endoscopy，2015，47(Suppl 1 UCTN)：E321-322.
[77]	Sousa M, Ribeiro I, Proença L, et al. Histoacryl injection for treatment of varices in the ascending colon[J]. Endoscopy, 2016，48(Suppl 1)：E285.
[78]	Chen WC，Hou MC，Lin HC，et al.An endoscopic injection with N-butyl-2- cyanoacrylate used for colonic variceal bleeding: a case report and review of the literature[J]．Am J Gastroenterol，2000，95(2)：540-542.
[79]	Weilert F, Shah JN, Marson FP, et al. EUS-guided coil and glue for bleeding rectal varix[J]. Gastrointest Endosc, 2012，76(4)：915-916.
[80]	Tsynman DN，DeCross AJ，Maliakkal B，et al.Novel use of EUS to successfully treat bleeding parastomal varices with N-butyl-2-cyanoacrylate[J]．Gastrointest Endosc，2014，79(6)：1007-1008; discussion 1008.
[81]	Kimura G，Hashimoto Y，Ikeda M．Successful obliteration of bleeding duodenal varices by EUS-guided injection of N-butyl-2-cyanoacrylate[J]．VideoGIE，2017，2 (11)：317-319.
[82]	Bahdi F，George R，Patel K．EUS-guided coiling and cyanoacrylate injection of ectopic duodenal varices[J]．VideoGIE，2020，6(1)：35-37.
[83]	Lee YT，Chan FK，Ng EK，et al.EUS-guided injection of cyanoacrylate for bleeding gastric varices[J]．Gastrointest Endosc，2000，52(2)：168-174.
[84]	Tseng Y，Ma L，Luo T，et al.Patient Response to Endoscopic Therapy for Gastroesophageal Varices Based on Endoscopic Ultrasound Findings[J]. Gut Liver，2018，12(5)：562-570.
[85]	Romero-Castro R，Pellicer-Bautista FJ，Jimenez-Saenz M，et al.EUS-guided injection of cyanoacrylate in perforating feeding veins in gastric varices：results in 5 cases[J]．Gastrointest Endosc，2007，66(2)：402-407.
[86]	Bhat YM，Weilert F，Fredrick RT，et al.EUS-guided treatment of gastric fundal varices with combined injection of coils and cyanoacrylate glue：a large U．S. experience over 6 years (with video) [J]．Gastrointest Endosc, 2016，83(6)：1164-1172.
[87]	Thiruvengadam SS，Sedarat A．The Role of Endoscopic Ultrasound (EUS) in the Management of Gastric Varices[J]．Curr Gastroenterol Rep，2021，23(1)：1.
[88]	Franco MC，Gomes GF，Nakao FS，et al.Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices[J]．World J Gastrointest Endosc，2014，6(6)：254-259.
[89]	Kouanda A，Binmoeller K，Hamerski C，et al.Safety and efficacy of EUS-guided coil and glue injection for the primary prophylaxis of gastric variceal hemorrhage[J]. Gastrointest Endosc，2021，94(2)：291-296.
[90]	Gonzalez JM，Giacino C，Pioche M，et al.Endoscopic ultrasound-guided vascular therapy: is it safe and effective? [J]．Endoscopy，2012，44(5)：539-542.
[91]	Bick BL，Al-Haddad M，Liangpunsakul S，et al.EUS-guided fine needle injection is superior to direct endoscopic injection of 2-octyl cyanoacrylate for the treatment of gastric variceal bleeding[J]．Surg Endosc，2019，33(6)：1837-1845.
[92]	Mohan BP，Chandan S，Khan SR，et al.Efficacy and safety of endoscopic ultrasound-guided therapy versus direct endoscopic glue injection therapy for gastric varices: systematic review and meta-analysis[J]. Endoscopy, 2020，52(4)：259-267.
[93]	McCarty TR，Bazarbashi AN，Hathorn KE，et al.Combination therapy versus monotherapy for EUS-guided management of gastric varices: A systematic review and meta-analysis[J]．Endosc Ultrasound，2020，9(1)：6-15.
[94]	陈明锴，丁震，肖勇，等．超声内镜联合胃镜治疗明显脾肾分流合并巨大胃静脉曲张的初步探讨[J]．中华消化内镜杂志，2016，33(10)：707-710.
[95]	Wang X，Yu S，Chen X，et al.Endoscopic ultrasound-guided injection of coils and cyanoacrylate glue for the treatment of gastric fundal varices with abnormal shunts：a series of case reports[J]．J Int Med Res，2019，47(4)：1802-1809.
[96]	王芳，刘仕倩，曾西，等．食管胃底静脉曲张伴自发性分流血管栓塞治疗的研究进展[J]．胃肠病学和肝病学杂志，2018，27(3)：346-350，355.
[97]	Robles-Medranda C，Nebel JA，Puga-Tejada M，et al.Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices[J]．World J Gastrointest Endosc，2021，13(1)：13-23.
[98]	Mukkada RJ，Antony R，Chooracken MJ，et al.Endoscopic ultrasound-guided coil or glue injection in post-cyanoacrylate gastric variceal re-bleed[J]．Indian J Gastroenterol，2018，37(2)：153-159.
[99]	Gubler C，Bauerfeind P．Safe and successful endoscopic initial treatment and long-term eradication of gastric varices by endoscopic ultrasound-guided Histoacryl (N-butyl-2-cyanoacrylate) injection[J]．Scand J Gastroenterol，2014，49(9)：1136-1142.
[100]	Kozieł S，Pawlak K，Błaszczyk Ł，et al.Endoscopic Ultrasound-Guided Treatment of Gastric Varices Using Coils and Cyanoacrylate Glue Injections: Results after 1 Year of Experience[J]．J Clin Med, 2019，8(11)：1786.
[101]	Fujii-Lau LL，Law R，Wong Kee Song LM，et al.Endoscopic ultrasound (EUS)- guided coil injection therapy of esophagogastric and ectopic varices[J]．Surg Endosc，2016，30(4)：1396-404.
[102]	Tang RSY，Kyaw MH，Teoh AYB，et al.Endoscopic ultrasound-guided cyanoacrylate injection to prevent rebleeding in hepatocellular carcinoma patients with variceal hemorrhage[J]．J Gastroenterol Hepatol，2020，35(12)：2192-2201.
[103]	Villanueva C，Colomo A，Bosch A，et al.Transfusion strategies for acute upper gastrointestinal bleeding[J]．N Engl J Med，2013，368(1)：11-21.
[104]	Wells M，Chande N，Adams P，et al.Meta-analysis：vasoactive medications for the management of acute variceal bleeds[J]．Aliment Pharmacol Ther，2012，35(11): 1267- 1278.
[105]	Huaringa-Marcelo J，Huaman MR，Branez-Condorena A，et al.Vasoactive Agents for the Management of Acute Variceal Bleeding：A Systematic Review and Meta-analysis[J]．J Gastrointestin Liver Dis，2021，30(1)：110-121.
[106]	Chavez-Tapia NC，Barrientos-Gutierrez T，Tellez-Avila F，et al.Meta-analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding - an updated Cochrane review[J]. Aliment Pharmacol Ther, 2011，34(5)：509-518.
[107]	Lee TH，Huang CT，Lin CC，et al.Similar rebleeding rate in 3-day and 7-day intravenous ceftriaxone prophylaxis for patients with acute variceal bleeding[J]．J Formos Med Assoc，2016，115(7)：547-552.
[108]	Lee YY，Tee HP，Mahadeva S．Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding[J]．World J Gastroenterol，2014，20(7)：1790-1796.
[109]	Rerknimitr R，Chanyaswad J，Kongkam P，et al.Risk of bacteremia in bleeding and nonbleeding gastric varices after endoscopic injection of cyanoacrylate[J]. Endoscopy，2008，40(8)：644-649.
[110]	Liu C，Ma L，Wang J，et al.Prophylactic use of antibiotics in endoscopic injection of tissue adhesive for the elective treatment of gastric varices：A randomized controlled study[J]．J Gastroenterol Hepatol, 2019，34(9)：1486-1491.
[111]	Jang WS，Shin HP，Lee JI，et al.Proton pump inhibitor administration delays rebleeding after endoscopic gastric variceal obturation[J]．World J Gastroenterol, 2014，20(45)：17127-17131.
[112]	Kim KR，Jun CH，Cho KM，et al.Can proton pump inhibitors reduce rebleeding following Histoacryl sclerotherapy for gastric variceal hemorrhage？[J]．Korean J Intern Med，2015，30(5)：593-601.
[113]	Komori K，Kubokawa M，Ihara E，et al.Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding[J]．World J Gastroenterol, 2017，23(3)：496-504.
[114]	Lin L，Cui B，Deng Y，et al.The Efficacy of Proton Pump Inhibitor in Cirrhotics with Variceal Bleeding：A Systemic Review and Meta-Analysis[J]．Digestion，2021, 102(2)：117-127.
[115]	Alhumaid S，Al Mutair A，Al Alawi Z，et al.Proton pump inhibitors use and risk of developing spontaneous bacterial peritonitis in cirrhotic patients：A systematic review and meta-analysis[J]．Gut Pathog，2021，13(1)：17.
[116]	Ma YJ，Cao ZX，Li Y，et al.Proton pump inhibitor use increases hepatic encephalopathy risk: A systematic review and meta-analysis[J]．World J Gastroenterol, 2019，25(21)：2675-2682.
[117]	Panés J，Terés J，Bosch J，et al.Efficacy of balloon tamponade in treatment of bleeding gastric and esophageal varices. Results in 151 consecutive episodes[J]．Dig Dis Sci，1988，33(4)：454-459.
[118]	Azoulay D，Castaing D，Majno P，et al.Salvage transjugular intrahepatic portosystemic shunt for uncontrolled variceal bleeding in patients with decompensated cirrhosis[J]．J Hepatol，2001，35(5)：590-597.
[119]	Zhu Y，Wang X，Xi X，et al.Emergency Transjugular Intrahepatic Portosystemic Shunt: an Effective and Safe Treatment for Uncontrolled Variceal Bleeding[J]．J Gastrointest Surg，2019，23(11)：2193-2200.
[120]	Maimone S，Saffioti F，Filomia R，et al.Predictors of Re-bleeding and Mortality Among Patients with Refractory Variceal Bleeding Undergoing Salvage Transjugular Intrahepatic Portosystemic Shunt (TIPS) [J]．Dig Dis Sci，2019，64(5)：1335-1345.
[121]	中国医师协会介入医师分会．中国门静脉高压经颈静脉肝内门体分流术临床实践指南[J]．中华肝脏病杂志，2019，27(8)：582-593.
[122]	Ninoi T，Nishida N，Kaminou T，et al.Balloon-occluded retrograde transvenous obliteration of gastric varices with gastrorenal shunt：long-term follow-up in 78 patients[J]．AJR Am J Roentgenol，2005，184(4)：1340-1346.
[123]	Yu Q，Liu C，Raissi D．Balloon-occluded Retrograde Transvenous Obliteration Versus Transjugular Intrahepatic Portosystemic Shunt for Gastric Varices：A Meta-Analysis[J]．J Clin Gastroenterol，2021，55(2)：147-158.
[124]	Mukund A，Rangarh P，Shasthry SM，et al.Salvage Balloon Occluded Retrograde Transvenous Obliteration for Gastric Variceal Bleed in Cirrhotic Patients With Endoscopic Failure to Control Bleed/Very Early Rebleed：Long-term Outcomes[J]．J Clin Exp Hepatol，2020，10(5)：421-428.
[125]	Orozco H，Mercado MA.The evolution of portal hypertension surgery: lessons from 1000 operations and 50 Years′ experience[J]．Arch Surg，2000，135(12)：1389-1393; discussion 1394.
[126]	Greig JD，Garden OJ，Anderson JR，et al.Management of gastric variceal haemorrhage[J]．Br J Surg，1990，77(3)：297-299.
[127]	Hashizume M，Tanoue K，Morita M，et al.Laparoscopic gastric devascularization and splenectomy for sclerotherapy-resistant esophagogastric varices with hypersplenism[J]. J Am Coll Surg，1998，187(3)：263-270.
[128]	Sharma A，Vijayaraghavan P，Lal R，et al.Salvage surgery in variceal bleeding due to portal hypertension[J]．Indian J Gastroenterol，2007，26(1)：14-17.
[129]	Cheng LF，Wang ZQ，Li CZ，et al.Low incidence of complications from endoscopic gastric variceal obturation with butyl cyanoacrylate[J]. Clin Gastroenterol Hepatol，2010，8(9)：760-766.
[130]	Guo YW，Miao HB，Wen ZF，et al.Procedure-related complications in gastric variceal obturation with tissue glue[J]．World J Gastroenterol，2017，23(43)：7746- 7755.
[131]	Cheng LF，Wang ZQ，Li CZ，et al.Treatment of gastric varices by endoscopic sclerotherapy using butyl cyanoacrylate：10 years′ experience of 635 cases[J]．Chin Med J (Engl), 2007，120(23)：2081-2085.
[132]	Hwang SS，Kim HH，Park SH，et al.N-butyl-2-cyanoacrylate pulmonary embolism after endoscopic injection sclerotherapy for gastric variceal bleeding[J]．J Comput Assist Tomogr，2001，25(1)：16-22.
[133]	谭玉勇，龚箭，刘德良. 肝硬化胃静脉曲张内镜下组织黏合剂注射治疗的并发症及防治策略[J]．世界华人消化杂志，2022，30(17)：775-782.
[134]	马佳丽，李坪，魏红山，等．食管胃底静脉曲张出血内镜治疗后排胶出血的危险因素分析[J]．临床肝胆病杂志，2018，34(1)：89-91.
[135]	Chen WC，Hou MC，Lin HC，et al.Bacteremia after endoscopic injection of N-butyl-2-cyanoacrylate for gastric variceal bleeding[J]. Gastrointest Endosc, 2001，54(2)：214-218.
[136]	Rerknimitr R，Chanyaswad J，Kongkam P，et al.Risk of bacteremia in bleeding and nonbleeding gastric varices after endoscopic injection of cyanoacrylate[J]. Endoscopy，2008，40(8)：644-649.
[137]	Martins FP，Macedo EP，Paulo GA，et al.Endoscopic follow-up of cyanoacrylate obliteration of gastric varices[J]．Arq Gastroenterol，2009，46(1)：81-84.
[138]	Ni Z，Chen H，Tang S，et al.The Efficacy and the Safety of Prophylactic N-Butyl -2-Cyanoacrylate Injection for Gastric Varices Using a Modified Injection Technique [J]．Surg Laparosc Endosc Percutan Tech, 2016，26(4)：e85-90.
[139]	Zeng X，Li N，Ma L，et al.Endoscopic Cyanoacrylate Injection with Lauromacrogol for Gastric Varices：Long-Term Outcomes and Predictors in a Retrospective Cohort Study[J]．J Laparoendosc Adv Surg Tech A，2019，29(9)：1135- 1143.

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