Research progress on immune mechanism of gastroesophageal reflux disease: immune inflammatory cascade acting as a novel therapeutic target

doi:10.3877/cma.j.issn.2095-7157.2022.03.006

Abstract

Abstract:

Gastroesophageal reflux disease (GERD) is a group of diseases with clinical manifestations and pathological changes caused by gastroduodenal content reflux into esophagus. Recently, some researchers have found that before the mucosal injury, the immune response occurred and caused the epithelial cells to vary in the pathogenesis of GERD. Meantime, the repair mechanism was activated, and acid / non acid reflux was the factor inducing immune and inflammatory response. So, to develop a novel treatment target, which can effectively block the occurrence of inflammatory cascade reaction attributed to reflux, would be a promising treatment of GERD.

Key words: Gastroesophageal reflux disease, Immune, Inflammatory, Pathogenesis, Treatment

Qianqian Chen, Yi Li, Enqiang Linghu. Research progress on immune mechanism of gastroesophageal reflux disease: immune inflammatory cascade acting as a novel therapeutic target[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(03): 145-147.

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