Study on the effectiveness of exhaled breath NO monitoring in the diagnosis of Helicobacter pylori infection

doi:10.3877/cma.j.issn.2095-7157.2023.01.011

Abstract

Abstract:

Objective

Retrospectively analyze the sensitivity of exhaled nitric oxide (NO) monitoring versus gastroscopic mucosal biopsy Helicobacter pylori test.

Methods

A retrospective analysis was performed for the clinical data of 182 patients admitted to the Department of Gastroenterology, Fuxing Hospital, Capital Medical University from January 2022 to December 2022, and the sensitivity and specificity of exhaled nitric oxide (NO) monitoring and the gold standard endoscopic mucosal biopsy Helicobacter pylori test were compared.

Results

A total of 182 patients were enrolled, including 79 males and 103 females, with an median age of (53.67±16.16) years. All patients underwent endoscopy, but 4.1% (8/182) of them did not complete the examination well with exhaled nitric oxide (NO) monitoring, so 8 patients were excluded. During the same period, the Helicobacter pylori test for endoscopic mucosal biopsy was 28.2% (49/174), and the patient′s NO exhalation value was set to >10 (positive) compared with the gold standard, with a sensitivity of 79.6% (39/49) and a specificity of 80% (100/125).

Conclusion

NO monitoring has high sensitivity and specificity for the diagnosis of Helicobacter pylori, which is worth serving as one of the methods for non-invasive monitoring of gastrointestinal inflammation.

Key words: Exhaled nitric oxide, Inflammation markers, H pylori, Digestive diseases

Ying Wang, Peilin Li, Quan Li, Hongmei Di, Chang Gao. Study on the effectiveness of exhaled breath NO monitoring in the diagnosis of Helicobacter pylori infection[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(01): 37-40.

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References 15

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金标准Hp	NO监测		总计
金标准Hp	阳性	阴性	总计
阳性	39	10	49
阴性	25	100	125
合计	64	110	174

金标准Hp	NO监测		总计
金标准Hp	阳性	阴性	总计
阳性	39	10	49
阴性	25	100	125
合计	64	110	174

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