Research progress on the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis

doi:10.3877/cma.j.issn.2095-7157.2023.02.008

Abstract

Abstract:

In addition to acid reflux and heartburn, the clinical manifestations of gastroesophageal reflux disease (GERD) can also include a series of extrA-esophageal complications, among which the incidence of respiratory system related diseases is high. Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis, inflammation and lung structure destruction. Long-term chronic microaspiration caused by gastroesophageal reflux plays an important role in the pathophysiological process of idiopathic pulmonary fibrosis. This article will review the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis, the role of acid suppression and anti-reflux therapy in the treatment of idiopathic pulmonary fibrosis.

Key words: Gastroesophageal reflux, Idiopathic pulmonary fibrosis, Acid inhibition, Anti-reflux surgery

Kunming Lv, Shasha Wang, Jun Wan, Enqiang Linghu. Research progress on the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(02): 121-124.

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