Comparison to multi-target fecal DNA testing and PuPu tube self-administered fecal immunochemical test in colorectal cancer screening in physical examination population

doi:10.3877/cma.j.issn.2095-7157.2024.01.008

Abstract

Abstract:

Objective

To compare the value of multi-target fecal DNA detection and PuPu Tube self-administered fecal immunochemical test (PuPu tube FIT) in colorectal cancer screening in physical examination population.

Methods

From January 2020 to December 2020, asymptomatic people who underwent physical examination in the Physical Examination Center of China Aerospace Science and Industry Corporation 731 Hospital were selected.Multi-target fecal DNA detection and PuPu tube FIT were used for primary screening.Colonoscopy was performed for those who were positive, and the screening results were analyzed and summarized.

Results

A total of 660 subjects completed multi-target fecal DNA detection andPuPu tube FIT, of which 42 cases were positive for multi-target fecal DNA detection, 55 cases were positive for PuPu tube FIT detection.The detection rate of colorectal cancer and advanced adenoma was 1.36% and the positive predictive value was 32.14% for those with positive multi-target fecal DNA detection. The detection rate of colorectal cancer and advanced adenoma was 0.30% and the positive predictive value was 7.69% for those with positive PuPu tube FIT detection, and the detection rate and positive predictive value of colorectal cancer and advanced adenoma by multi-target fecal DNA detection were higher than those by PuPu tube FIT, and the differences were statistically significant (P<0.05).

Conclusion

Compared with PuPu tube FIT, multi- target fecal DNA detection has higher detection rate and positive predictive value for colorectal cancer and advanced adenoma. Therefore, multi-target fecal DNA detection has a higher screening value for colorectal cancer in physical examination population.

Key words: Multi-target fecal DNA detection, PuPu Tube FIT, Colorectal cancer, Advanced adenomas, Physical examination population

Xuqian Zhang, Yifan Gong, Aijun Zhai. Comparison to multi-target fecal DNA testing and PuPu tube self-administered fecal immunochemical test in colorectal cancer screening in physical examination population[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2024, 11(01): 33-36.

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References 20

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项目	阳性例数	癌与进展期腺瘤例数(检出率%)	癌与进展期腺瘤阳性预测值(%)	非进展期腺瘤例数(检出率%)	非进展期腺瘤阳性预测值(%)
MT-sDNA(n＝28)	42	9 (1.36)	32.14	7 (1.06)	25.00
噗噗管法FIT (n＝26)	55	2 (0.30)	7.69	6 (0.91)	23.08
χ 2值		4.492	4.969	0.078	2.908
P值		0.034	0.026	0.781	0.088

项目	阳性例数	癌与进展期腺瘤例数(检出率%)	癌与进展期腺瘤阳性预测值(%)	非进展期腺瘤例数(检出率%)	非进展期腺瘤阳性预测值(%)
MT-sDNA(n＝28)	42	9 (1.36)	32.14	7 (1.06)	25.00
噗噗管法FIT (n＝26)	55	2 (0.30)	7.69	6 (0.91)	23.08
χ 2值		4.492	4.969	0.078	2.908
P值		0.034	0.026	0.781	0.088

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