To explore the correlation between helicobacter pylori (Hp) infection and lipid profile among the old male population.

The men more than 60 years old who had physical examination in the Chinese PLA General Hospital from January to December 2015 were recruited as the research objects. Hp infection was determined by ¹³C urea breath test and lipid profile by automatic biochemical analyzer. Multivariate logistic regression model was used to analyze the possible correlation between serum lipid profile and Hp infection.

A total of 898 old physical examination personnel was included in this study, with an average age of 75.68 ± 10.22. The study identified 468 instances of Helicobacter pylori infection, representing an infection rate of 52.12%. The prevalence of Low-HDL-C in Hp infectious group was lower than that in non-infectious group (P= 0.005). Multivariate logistic regression analysis showed that, after adjusting for age, blood urea nitrogen, neutrophils, lymphocytes and alkaline phosphatase, the risk of Hp infection increased by 20.5% (OR = 1.205, 95%CI: 1.030-1.410) and 36.1% (OR=1.361, 95%CI: 1.143-1.620) for every 1 mmol/L increment of TC and LDL-C, respectively. the risk of Hp infection decreased by 37.4% (OR=0.626, 95%CI: 0.424-0.925) for every 1 mmol/L increment of HDL-C. In the group with higher levels of albumin and hemoglobin, the correlation between serum lipid profile and prevalence of Hp infection was more profound.

Higher levels of TC and LDL-C may be associated with higher prevalence of Hp infection, while higher levels of HDL-C may be associated with lower risk of Hp infection. The association between lipid profile and Hp infectious rate may be affected by nutritional status of old male population.