Abstract:

Chronic kidney disease （ CKD ） is a global public health problem.Epidemiological studies have shown that the prevalence of CKD in the general population is increasing.Upper gastrointestinal bleeding （ UGIB ） is the most common complication of CKD，and CKD is an independent predictor of upper gastrointestinal bleeding.The incidence，mortality and rebleeding rate of upper gastrointestinal bleeding in patients with chronic kidney disease are higher.At present，the mechanism of upper gastrointestinal bleeding in patients with chronic kidney disease is not clear，but it is generally believed to be related to the accumulation of uremic toxins，platelet dysfunction，increased gastrointestinal hormones，gastrointestinal dysfunction，and the use of anticoagulant drugs during dialysis.Patients with end-stage renal disease have more underlying diseases and late complications.This article summarizes the research progress of chronic kidney disease complicated with upper gastrointestinal bleeding at home and abroad in recent years，and summarizes the pathogenesis，etiology，treatment，prevention and other aspects，so that clinicians can understand this disease and achieve the purpose of early diagnosis and professional treatment.

Key words: Chronic cidney disease, Upper gastrointestinal bleeding, Pathogenesis, Etiology