Study on trauma and inflammatory changes in super minimally invasive surgery for gastric cancer

doi:10.3877/cma.j.issn.2095-7157.2025.02.007

Abstract

Abstract:

Objective

To evaluate the impact of super minimally invasive surgery (SMIS) on the human body by comparing inflammatory factors between gastric cancer patients undergoing SMIS and organ resection surgery (ORS).

Methods

A prospective randomized study included 20 gastric cancer patients who underwent SMIS in the of Department of Gastroenterology from May 2023 to April 2024, and 20 gastric cancer patients who underwent ORS in the General Surgery Department of PLA General Hospital. Enzymelinked immunosorbent assay was used to detect changes in the concentrations of six inflammatory factorstumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), interleukin-4(IL-4),interleukin-10 (IL-10),and transforming growth factor-beta (TGF-β)-in serum samples collected 1 day before surgery and 3 days after surgery.

Results

There were no statistically significant differences in the concentrations of the six inflammatory factors before and after SMIS (P > 0.05), nor were there significant differences before and after ORS (P > 0. 05).

Conclusion

In terms of controlling early postoperative inflammatory responses, SMIS shows comparable performance to ORS. Future studies may extend the observation time window or incorporate more inflammatory indicators to comprehensively evaluate the effects of different surgical procedures on traumatic inflammatory responses.

Key words: Gastric cancer, Super minimally invasive surgery, Organ resection surgery, Organ-preserving surgery, Traumatic inflammation

Pan Xiao, Yang Yan, Huikai Li, Jing Hao, Xiao Zhang, Qianqian Chen, Enqiang Linghu. Study on trauma and inflammatory changes in super minimally invasive surgery for gastric cancer[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2025, 12(02): 103-106.

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References 22

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项目	SMIS 组（n = 20）	ORS（n = 20）	P 值
性别			0.405
男	18(90)	15(75)
女	2(10)	5(25)
年龄(岁)	62.15(9.63)	57.55(9.63)	0.139
BMI(kg/m²)	25.44(2.62)	24.36(4.45)	0.353
吸烟史	7(35)	8(40)	1.0
饮酒史	11(55)	10(50)	1.0

项目	SMIS 组（n = 20）	ORS（n = 20）	P 值
性别			0.405
男	18(90)	15(75)
女	2(10)	5(25)
年龄(岁)	62.15(9.63)	57.55(9.63)	0.139
BMI(kg/m²)	25.44(2.62)	24.36(4.45)	0.353
吸烟史	7(35)	8(40)	1.0
饮酒史	11(55)	10(50)	1.0

炎症指标	SMIS 术前	SMIS 术后	P 值
TNF-a	3.28(5.01)	5.78(5.43)	0.115
IL-1β	2.77(2.49)	3.71(1.4)	0.609
IL-4	4.07(0.83)	3.88(0.88)	0.632
IL-6	5.35(1.46)	4.84(1.11)	0.107
IL-10	5.27(0.74)	4.88(0.68)	0.108
TGF-β	7.84(1.55)	7.15(2.06)	0.257

炎症指标	SMIS 术前	SMIS 术后	P 值
TNF-a	3.28(5.01)	5.78(5.43)	0.115
IL-1β	2.77(2.49)	3.71(1.4)	0.609
IL-4	4.07(0.83)	3.88(0.88)	0.632
IL-6	5.35(1.46)	4.84(1.11)	0.107
IL-10	5.27(0.74)	4.88(0.68)	0.108
TGF-β	7.84(1.55)	7.15(2.06)	0.257

炎症指标	ORS 术前	ORS 术后	P 值
TNF-a	2.45(5.01)	2.45(3.34)	0.332
IL-1β	1.53(0.62)	1.53(1.4)	0.186
IL-4	2.61(0.88)	2.61(0.78)	0.981
IL-6	3.13(1.8)	2.27(1.71)	0.206
IL-10	3.19(1.12)	3.14(1.09)	0.845
TGF-β	4.4(2.92)	3.71(2.75)	0.896

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