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Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition) ›› 2025, Vol. 12 ›› Issue (04): 267-272. doi: 10.3877/cma.j.issn.2095-7157.2025.04.008

• Original Article • Previous Articles    

Analysis of risk factors for progression in suspected superficial duodenal papillary neoplastic lesions

Yawen Liang1,2, Yaqi Zhai2, Mingyang Li2,()   

  1. 1Chinese PLA Medical School, Beijing 100853, China
    2Department of Gastroenterology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2025-09-05 Online:2025-11-15 Published:2026-01-12
  • Contact: Mingyang Li

Abstract:

Objective

To identify risk factors through clinical features to aid in the early diagnosis and risk stratification of suspected superficial duodenal papillary neoplasms.

Methods

A retrospective analysis was conducted on clinical data from 168 patients with suspected superficial duodenal papillary tumors who underwent endoscopic or surgical resection at the First Medical Center of the General Hospital of the People′s Liberation Army between December 2014 and December 2024.Based on pathological classification, the patients were categorized into two groups: a low-grade intraepithelial neoplasia group and an early carcinoma group.

Results

Univariate analysis showed that the early cancer group was older and had significantly higher rates of jaundice and weight loss, elevated levels of CA199, ALT, AST, ALP, γ-GGT, and TBIL, as well as decreased lymphocyte count and hemoglobin (Hb) levels.In terms of imaging findings, the early cancer group demonstrated higher positive imaging rates, more significant biliary dilation, and pancreatic duct dilation.Multivariate analysis identified age, jaundice, biliary dilation, and elevated CA199 as independent risk factors for early tumor progression.

Conclusion

Old age, jaundice, biliary dilation, and elevated CA199 are independent risk factors for progression in patients with suspected superficial duodenal papillary neoplasms.Early and accurate identification of lesions based on clinical data, along with improved diagnostic accuracy, can facilitate early intervention and optimize treatment strategies.

Key words: Duodenal papillary neoplasms, Low-grade intraepithelial neoplasia (LGIN), Early-stage cancer, Precancerous lesions, Differential diagnosis

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