To explore the effect of polyethylene glycol electrolyte (PEG)solutions combined with linaclotide in bowel preparation for colonoscopy.

A retrospective analysis was conducted on 170 patients who underwent colonoscopy at Baoding First Central Hospital from June 2021 to March 2022.They were divided into an observation group and a control group according to whether they took linaclotide during bowel preparation, with 85 cases in each group.The control group used PEG for intestinal preparation alone, and took 1 000 ml of polyethylene glycol electrolyte (SF-PEG) solution orally at 20: 00 the night before colonoscopy, and took 2 000 ml of SF-PEG solution orally again 4 to 6 hours before colonoscopy.The observation group received PEG combined with linaclotide capsules for intestinal preparation, and took 2 linaclotide capsules (580 μg) orally at 20: 00 the night before colonoscopy, and 2 000 ml of SF-PEG solution orally 4-6 hours before colonoscopy.The two groups were compared in terms of medication tolerance, adverse reaction rate, intestinal cleanliness, cecal intubation rate, and polyp/adenoma detection rate.

The qualified rate of intestinal preparation in the observation group was 89.02% (82 cases), and the qualified rate in the control group was 91.57% (83 cases), with no significant difference between the two groups (P>0.05).The medication tolerance rate in the observation group was 92.68%, and that in the control group was 77.11%, with a significant difference between the two groups (P<0.05).The percentage of patients willing to undergo bowel preparation again in the observation group was 87.80%, while that in the control group was 65.06%, with a statistically significant difference (P<0.05).The rates of nausea, abdominal distension and total adverse reactions in the observation group were lower than those in the control group (P<0.05). There was no statistically significant difference in the Boston score of each colon segment and the total score between the two groups (P>0.05). The cecal intubation rate, polyp detection rate, and adenoma detection rate in the observation group were 98.78%, 32.93%, and 18.29%, respectively; in the control group, the cecal intubation rate, polyp detection rate, and adenoma detection rate were 98.80%, 30.12%, and 18.07%, respectively. There was no significant difference between the two groups (P>0.05).

Compared with 3L SF-PEG in fractions, 2L SF-PEG combined with 2 linaclotide tablets achieved equivalent bowel preparation effects, but with better medication tolerance and lower adverse reaction rates.