To investigate the safety and feasibility of linaclotide combined with low-dose Compound Polyethylene Glycol Electrolytes Powder (PEG) for bowel preparation in constipated patients.

A total of 300 patients scheduled for colonoscopy at the Endoscopy Center of Baoding First Central Hospital from March 2022 to October 2023 were enrolled.Participants were randomly divided into two groups using a random number table.Group A as control group, received 4L-PEG for bowel preparation.Group B as Experimental group, received 870μg linaclotide combined with 3L-PEG for bowel preparation.Bowel cleanliness was evaluated using the Boston Bowel Preparation Scale (BBPS) scores (right colon, mid-colon, distal colon, and total score). Adverse event rates were compared between groups.

Group B demonstrated significantly higher BBPS scores in the right colon, mid-colon, distal colon, and total score compared to Group A (P<0.05). Additionally, the adverse event rate in Group B was significantly lower than that in Group A, with the difference being statistically significant (P<0.05).

The bowel preparation protocol combining 870 μg linaclotide with 3L-PEG provides superior bowel cleanliness to the conventional 4L-PEG regimen, with a lower incidence of adverse events.