To investigate the awareness of gastric cancer endoscopic screening among medical staff and residents in Lhasa, Xizang, and to evaluate methods for improving compliance with early gastric cancer screening.

A single-center cross-sectional study was conducted using questionnaires administered to medical staff in Lhasa and patients and their families visiting Lhasa People′s Hospital.

A total of 145 valid questionnaires were collected from medical staff, primarily from gastroenterology (28.3%), other internal medicine departments (33.1%), and general practice (13.1%).The careful reading rate of gastric cancer screening consensus guidelines among gastroenterology staff was below 10%.Gastroenterology staff demonstrated significantly higher awareness than non-gastroenterology staff in distinguishing early from advanced gastric cancer (92.3% vs. 65.6%) and recommending screening for individuals over 45 years (100% vs. 90.3%, P<0.05). A total of 125 valid questionnaires were collected from residents, with Tibetans accounting for 96.8%.Awareness of family gastric cancer history was low (19.2% unaware); 64.0% were unaware of high-incidence cancers in Xizang, with only 17.6% recognizing gastric cancer as high-incidence; 71.2% were unaware of the relationship between Helicobacter pylori and gastric cancer; only 27.2% believed that gastroscopy has a significant role in preventing gastric cancer; 45.6% believed gastric cancer always presents with symptoms; 74.4% were willing to undergo screening.Residents with family history relied more on professional channels (57.1%) and interpersonal networks (42.9%), and showed significantly higher rates of H. pylori testing (57.1% vs. 34.0%) and gastroscopy (57.1% vs. 21.3%) compared to those without family history, with particularly higher acceptance of painless gastroscopy (42.9% vs. 12.8%).

Medical staff in Lhasa demonstrate positive attitudes toward gastric cancer endoscopic screening, but gastroenterology professionals have insufficient mastery of screening guidelines, and non-gastroenterology staff have insufficient understanding of early gastric cancer concepts.Residents have low awareness of gastric cancer risk factors and early cancer screening, but family history significantly improves their screening behavior.Guidelines training for medical staff should be strengthened, with particular emphasis on education for non-gastroenterology professionals, and health education should be conducted in combination with Tibetan cultural characteristics to promote the implementation of gastric cancer screening.