To construct a systematic nursing protocol for bowel preparation with polyethylene glycol electrolyte powder combined with simethicone in colonoscopy, and to explore its application efficacy.

A total of 92 inpatients who underwent colonoscopy in our hospital from March 2023 to May 2025 were selected and divided into the control group and the study group by the random number table method, with 46 cases in each group.Considering that polyethylene glycol electrolyte powder is commonly used alone without routine defoaming agents and standardized nursing in clinical practice, the control group received the traditional regimen (polyethylene glycol electrolyte powder combined with routine nursing without simethicone); the study group adopted simethicone in accordance with guideline recommendations combined with systematic nursing.The bowel cleansing quality, intra- intestinal defoaming effect, incidence of adverse reactions and nursing satisfaction were compared between the two groups.

In the study group, the effective rate of bowel cleansing and the excellent and good rate of defoaming effect were both 91.30%, which were significantly higher than 65.22% and 60.87% in the control group.The incidence of adverse reactions in the study group was 4.35%, significantly lower than 30.43% in the control group; the nursing satisfaction rate was 97.83%, higher than 86.96% in the control group, with statistically significant differences between groups (P<0.05).

The newly constructed systematic nursing protocol combined with polyethylene glycol electrolyte powder and simethicone can significantly improve bowel cleansing quality and defoaming effect, reduce adverse reactions such as abdominal pain, abdominal distension and nausea, and increase nursing satisfaction.The combination of medication and refined nursing presents a remarkable synergistic effect, which is worthy of clinical promotion.