中华胃肠内镜电子杂志 ›› 2018, Vol. 05 ›› Issue (01) : 38 -40. doi: 10.3877/cma.j.issn.2095-7157.2018.05.005 × 扫一扫
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Shuyi Zhang1, Shusen Wang1, Mo Dong1, Lei Shi1, Yanru Li1, Wen Li1,†()
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张姝翌, 王树森, 董默, 石磊, 李彦如, 李文. 埃索美拉唑预防氯吡格雷相关性胃黏膜损伤的研究[J]. 中华胃肠内镜电子杂志, 2018, 05(01): 38-40.
Shuyi Zhang, Shusen Wang, Mo Dong, Lei Shi, Yanru Li, Wen Li. The study of prevention effect of esomeprazole on clopidogrel-induced gastric mucosal injury[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2018, 05(01): 38-40.
探讨埃索美拉唑是否可以预防氯吡格雷导致的胃黏膜损伤。
120只SD大鼠随机分为3组,每组40只,分别给予生理盐水、氯吡格雷、埃索美拉唑联合氯吡格雷灌胃。分别于给药后7 d、14 d、21 d和28 d处死大鼠,使用HE染色对胃黏膜进行组织病理学观察,使用Guth法对胃黏膜损伤进行评分。
埃索美拉唑可显著降低胃黏膜损伤的发生率(65.0% vs 42.5%,P=0.044)。用药后7 d开始,单用氯吡格雷组小鼠胃黏膜出现明显损伤,损伤评分在14 d达到高峰(6.85±0.99),而联合用药组在各时间点胃黏膜损伤的程度均较单用氯吡格雷组更轻微(P<0.01),且损伤程度随用药时间延长无显著变化。
氯吡格雷可导致胃黏膜损伤,且损伤程度在14 d达到高峰,而埃索美拉唑可有效预防氯吡格雷相关性胃黏膜损伤。
To evaluate the prevention effect of esomeprazole on clopidogrel-induced gastric mucosal lesions.
One hundred and twenty SD rats were divided into three groups randomly, which were intragastric administrated with normal saline, clopidogrel and esomeprazole combined with clopidogrel, respectively.The rats were executed after 7 days, 14 days, 21 days and 28 days, 10 rats for each group each time, then the stomach mucosas were observed and the scores of gastric mucosal injury were evaluated by using Guth system.
Esomeprazole could significantly reduce the incidence of mucosal injury (65.0% vs 42.5%, P=0.044). The scores of ulcer index of combined group were lower than that of clopidogrel group.The degree of injury of combined group did not change significantly over time.
Clopidogrel could induce gastric mucosal injury. Esomeprazole could effectively prevent clopidogrel-induced gastric mucosal injury.