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中华胃肠内镜电子杂志 ›› 2021, Vol. 08 ›› Issue (01) : 37 -41. doi: 10.3877/cma.j.issn.2095-7157.2021.01.007

所属专题: 文献

综述

血清胃蛋白酶原、胃泌素-17、幽门螺杆菌抗体检测在筛查胃癌风险人群中的价值分析
刘炜钰1, 高孝忠2,()   
  1. 1. 264003 山东,滨州医学院;264200 山东,威海市立医院
    2. 264200 山东,威海市立医院
  • 收稿日期:2020-07-13 出版日期:2021-02-15
  • 通信作者: 高孝忠
  • 基金资助:
    威海市科技发展计划(2017GNS11); 山东省重点研发计划(2019GSF108190)

Analysis of the value of serum pepsinogen, gastrin-17, and Helicobacter pylori antibody detection in screening gastric cancer risk groups

Weiyu Liu1, Xiaozhong Gao2,()   

  1. 1. Binzhou Medical University, 264003 Shandong; Weihai Municipal Hospital, 264200 Weihai, China
    2. Weihai Municipal Hospital, 264200 Weihai, China
  • Received:2020-07-13 Published:2021-02-15
  • Corresponding author: Xiaozhong Gao
引用本文:

刘炜钰, 高孝忠. 血清胃蛋白酶原、胃泌素-17、幽门螺杆菌抗体检测在筛查胃癌风险人群中的价值分析[J]. 中华胃肠内镜电子杂志, 2021, 08(01): 37-41.

Weiyu Liu, Xiaozhong Gao. Analysis of the value of serum pepsinogen, gastrin-17, and Helicobacter pylori antibody detection in screening gastric cancer risk groups[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2021, 08(01): 37-41.

胃癌是目前常见的消化道恶性肿瘤之一,死亡率高。早诊早治对于胃癌患者改善预后具有重要意义。血清分子标志物凭借成本较低、简单易行、痛苦小、可动态监测等优点在胃癌及癌前疾病筛查、预后评估等方面发挥着重要的作用,在国内外临床应用较为广泛。本文就血清胃蛋白酶原、胃泌素-17、幽门螺杆菌抗体检测在筛查胃癌风险人群中的价值分析做一综述。

Gastric cancer is one of the most common malignant tumors of the digestive tract, with a high mortality rate. Early diagnosis and treatment is of great significance to patients with gastric cancer. Serum molecular markers play an important role in the screening and prognostic evaluation of gastric cancer and precancerous diseases due to their advantages of low cost, simple and easy operation, little pain, and dynamic monitoring, and are widely used in clinical applications at home and abroad.This article reviews the value of serum pepsinogengastrin-17, and Helicobacter pylori antibody detection in screening gastric cancer risk groups.

表1 不同胃黏膜组织学状态的血清学分子标志物测定结果
[1]
杜奕奇,蔡全才,廖专,等. 中国早期胃癌筛查流程专家共识意见(草案)(2017年,上海)[J]. 胃肠病学,2018,23(2):92-97.
[2]
Mansour-ghanaei F, Joukar F, Rajpout Y, et al. Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti-CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran[J]. Asian Pac J Cancer Prev, 2014, 15(18): 7635-7638.
[3]
Wang K, Liang Q, Li X, et al. MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome[J]. Gut, 2016, 65(10): 1619-1631.
[4]
Waldum HL, Hauso Ø, Sørdal ØF, et al. Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach[J]. Dig Dis Sci, 2015, 60(6): 1522-1527.
[5]
薛辉,辛凤池,穆素恩,等. 血清胃蛋白酶原联合G-17对萎缩性胃炎及胃癌早期诊断价值[J]. 现代生物医学进展,2017,17(11):2119-2122.
[6]
Xu W, Chen G, Shao Y, et al. Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells[J]. Cancer Letters, 2013, 332(1): 11-18.
[7]
Tang E, Wang Y, Liu T, et al. Gastrin promotes angiogenesis by activating HIF-1α/β-catenin/VEGF signaling in gastric cancer[J]. Gene, 2019, 704: 42-48.
[8]
朱春平,赵建业,申晓军,等. 血清胃泌素-17联合胃蛋白酶原检测对胃癌诊断价值的多中心临床研究[J]. 中华消化内镜杂志,2017,34(1):19-23.
[9]
Chen C, HsuY, Lee C, et al. Central Obesity and H. pylori Infection Influence Risk of Barrett′s Esophagus in an Asian Population[J]. PloS One, 2016, 11(12): e167815.
[10]
Akazawa Y, Isomoto H, Matsushima K, et al. Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis[J]. PloS One, 2013, 8(12): e82322.
[11]
Yang F, Xu Y, Liu C, et al. NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression[J]. Cell Death Dis, 2018, 9(1): 12.
[12]
姜静宜,孙丽萍. 胃黏膜"血清学活检"与胃糜烂溃疡性疾病[J]. 胃肠病学和肝病学杂志,2015,24(2):140-142.
[13]
张苗苗,赵志鹏,李晓晨,等. 幽门螺杆菌抗体分型检测及分型与胃部疾病的相关性分析[J]. 标记免疫分析与临床,2020,27(8):1305-1309.
[14]
Correa P, Piazuelo MB. The gastric precancerous cascade[J]. J Dig Dis, 2012, 13(1): 2-9.
[15]
Vannella L, Lahner E, Osborn J, et al. Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis[J]. Aliment Pharmaclol Ther, 2010, 31(9): 1042-1050.
[16]
Korstanje A, den Hartog G, Biemond I, et al. The serological gastric biopsy: a non-endoscopical diagnostic approach in management of the dyspeptic patient: significance for primary care based on a survey of the literature[J]. Scand J Gastroenterol, 2002, 236 (Suppl): 22-26.
[17]
Bornschein J, Selgrad M, Wex T, et al. Serological assessment of gastric mucosal atrophy in gastric cancer[J]. BMC Gastroenterol, 2012, 12(1): 10.
[18]
Shafaghi A, Mansour-ghanaei F, Joukar F, et al. Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions[J]. Asian Pac J Cancer Prev, 2013, 14(6): 3931-3936.
[19]
Adamu MA, Weck MN, Rothenbache D, et al. Incidence and risk factors for the development of chronic atrophic gastritis: five year follow-up of a population-based cohort study[J]. Int J Cancer, 2011, 128(7): 1652-1658.
[20]
Varis K, Sipponen P, Laxen F, et al. Implications of serum pepsinogen I in early endoscopic diagnosis of gastric cancer and dysplasia.Helsinki Gastritis Study Group[J]. Scand J Gastroenterol, 2000, 35(9): 950-956.
[21]
Mlki K. Gastric cancer screening using the serum pepsinogen test method[J]. Gastric Cancer, 2006, 9(4): 245-253.
[22]
Sierra R, Une C, Ramirez V, et al.Association of serum pepsinogen with atrophic body gastritis in Costa Rica[J]. Clin Exp Med, 2006, 6(2): 72-78.
[23]
Sun L, Tu H, Liu J, et al. A comprehensive evaluation of fasting serum gastrin-17 as a predictor of diseased stomach in Chinese population[J]. Scand J Gastroenterol, 2014, 49(10): 1164-1172.
[24]
Maddalo G, Spolverato Y, Rugge M, et al. Gastrin: from pathophysiology to cancer prevention and treatment[J]. Eur J Cancer Prev, 2014, 23(4): 258-263.
[25]
Väänänen H, Vauhkonem M, Helske T, et al. Non-endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study[J]. Eur J Gastroenterol Hepatol, 2003, 15(8): 885-891.
[26]
Lorente S, Doiz O, Serrano MT, et al. Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells[J]. Gut, 2002, 50(1): 13-18.
[27]
Ohkusa T, Miwa H, Nomura T, et al. Improvement in serum pepsinogens and gastrin in long-term monitoring after eradication of Helicobacter pylori: comparison with H. pylori-negative patients[J]. Alim Pharmacol Ther, 2004, 20(s1): 25-32.
[28]
Sun LP, Gong YH, Wang L, et al. Serum pepsinogen levels and their influencing factors: a population-based study in 6990 Chinese from North China[J]. World J Gastroenterol, 2007, 13(48): 6562-6567.
[29]
Venerito M, Varbanova M, Röhl F, et al. Oxyntic gastric atrophy inHelicobacter pylori gastritis is distinct from autoimmune gastritis[J]. J Clin Pathol, 2016, 69(8): 677-685.
[30]
Gong Y, Wei W, Jing WL, et al. Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organ Functions[J]. Dig Dis Sci, 2015, 60(6): 1748-1754.
[31]
Wroblewskil E, Pritchard DM, Carter S, et al. Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression[J]. Biochem J, 2002, 365(Pt 3): 873-879.
[32]
Mizuno S, Miki I, Ishida T, et al. Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis[J]. Dig Dis Sci, 2010, 55(11): 3132-3137.
[33]
Pradeep A, Sharma C, Sathyanarayana P, et al. Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells[J]. Oncogene, 2004, 23(20): 3689-3699.
[34]
Wang TC, Dangler CA, Chen D, et al.Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer[J]. Gastroenterology, 2000, 118(1): 36-47.
[35]
Watabe H, Mittsushima T, Yamaji Y, et al. Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study[J]. Gut, 2005, 54(6): 764-768.
[36]
SIPPONEN P, RANTA P, HELSKE T, et al. Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study[J]. Scand J Gastroenterol, 2002, 37(7): 785-791.
[37]
Tu H, Sun L, Dong X, et al. A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study[J]. Am J Gastroenterol, 2017, 112(5): 704-715.
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