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中华胃肠内镜电子杂志 ›› 2021, Vol. 08 ›› Issue (01) : 42 -45. doi: 10.3877/cma.j.issn.2095-7157.2021.01.008

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综述

COL11A1在消化系统肿瘤中的研究进展
刘雪影1, 许良璧2,(), 李大欢2, 王景林1   
  1. 1. 550000 贵阳,贵州医科大学
    2. 550000 贵阳,贵州医科大学附属医院内镜中心
  • 收稿日期:2020-04-23 出版日期:2021-02-15
  • 通信作者: 许良璧

Research Progress of COL11A1 in Digestive System Tumors

Xueying Liu1, Liangbi Xu2,(), Dahuan Li2, Jinglin Wang1   

  1. 1. Guizhou Medical University, Guiyang 550000, China
    2. Digestive Endoscopy Center of the Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China
  • Received:2020-04-23 Published:2021-02-15
  • Corresponding author: Liangbi Xu
引用本文:

刘雪影, 许良璧, 李大欢, 王景林. COL11A1在消化系统肿瘤中的研究进展[J]. 中华胃肠内镜电子杂志, 2021, 08(01): 42-45.

Xueying Liu, Liangbi Xu, Dahuan Li, Jinglin Wang. Research Progress of COL11A1 in Digestive System Tumors[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2021, 08(01): 42-45.

胶原蛋白XI(collagen type XI,COL11)是一种次要胶原,其主要生理功能是调节主要胶原纤维的直径。COL11A1编码前胶原XI A1和成熟胶原XI A1的α1链,通常存在于软骨中,它在肌肉骨骼性疾病中的致病作用已被证实。但作为肿瘤微环境的重要成分之一,COL11A1近年来引发越来越多的关注。研究表明,COL11A1可由癌相关成纤维细胞(CAFs)产生,可促进肿瘤上皮间质转化(EMT),是多种癌症发生、发展的重要因素,与肿瘤侵袭、转移、耐药等有关。本文将着重阐述COL11A1在常见消化系统肿瘤恶性进展中的作用及机制,以期对消化道肿瘤的治疗及后续研究方面提供有价值的参考。

Collagen XI (collagen type XI, COL11) is a kind of secondary collagen. Its main physiological function is to regulate the diameter of main collagen fibers. COL11A1 encodes the α1 chain of procollagen 11A1 and mature collagen 11A1, which usually exists in cartilage and its pathogenic role in various musculoskeletal diseases has been confirmed. However, as one of the important components of tumor microenvironment, COL11A1 has attracted more and more attention in recent years.Studies have shown that COL11A1 is secreted by cancer-related fibroblasts (CAFs), can promote tumor epithelial mesenchymal transition (EMT), is an important factor in the occurrence and development of various cancers, is related to tumor invasion, metastasis, drug resistance, etc. This review will focus on the role and mechanism of COL11A1 in the malignant progression of common digestive system tumors, so as to provide valuable reference for the treatment and follow-up research of digestive system tumors.

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