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中华胃肠内镜电子杂志 ›› 2022, Vol. 09 ›› Issue (03) : 152 -155. doi: 10.3877/cma.j.issn.2095-7157.2022.03.008

综述

长链非编码RNA在胃肠道间质瘤中的研究进展
高福来1, 赵东强1,()   
  1. 1. 050000 石家庄,河北医科大学第二医院消化内科
  • 收稿日期:2021-11-28 出版日期:2022-08-15
  • 通信作者: 赵东强
  • 基金资助:
    河北省重点研发计划国际科技合作专项项目(18397738D)

Research progress of long noncoding RNA in gastrointestinal stromal tumor

Fulai Gao1, Dongqiang Zhao1,()   

  1. 1. Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2021-11-28 Published:2022-08-15
  • Corresponding author: Dongqiang Zhao
引用本文:

高福来, 赵东强. 长链非编码RNA在胃肠道间质瘤中的研究进展[J/OL]. 中华胃肠内镜电子杂志, 2022, 09(03): 152-155.

Fulai Gao, Dongqiang Zhao. Research progress of long noncoding RNA in gastrointestinal stromal tumor[J/OL]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(03): 152-155.

长链非编码RNA(lncRNA)是一类长度超过200个核苷酸的非蛋白质编码转录本,具有调控基因表达但不表现任何蛋白质编码功能的非编码RNA(ncRNA),目前已成为继microRNA之后又一研究的新热。lncRNA利用修饰、指引和支架三种主要作用模式通过表观遗传学调控、转录调控、转录后调控等机制参与调控消化系统肿瘤的进展。胃肠道间质瘤(GIST)是消化道最常见的间叶源性肿瘤,其发生主要源自于KIT基因或血小板源性生长因子受体α(PDGFRA)基因的突变所致。本文就lncRNA在GIST发病中的作用作一综述。

Long noncoding RNA (lncRNA), a class of transcripts with a length of more than 200 nucleotides, noncoding RNAs (ncRNA) that regulate gene expression but do not exhibit any protein coding function, has become a new hot topic following the microRNA study. lncRNA uses three main modes of action: modification, guidance, and scaffolding to participate in the regulation of digestive system tumor progression through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other mechanisms. Gastrointestinal Stromal Tumor(GIST)are the most common mesenchymal-derived tumors of the digestive tract, mainly due to mutations in the kit gene or the Platelet-Derived Growth Factor Receptor alpha (PDGFRα) gene. This article reviews the role of lncRNA in the pathogenesis of gastrointestinal stromal tumor.

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