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中华胃肠内镜电子杂志

中华胃肠内镜电子杂志 ›› 2023, Vol. 10 ›› Issue (01) : 37 -40. doi: 10.3877/cma.j.issn.2095-7157.2023.01.011

论著

呼出气一氧化氮监测诊断幽门螺杆菌感染的有效性研究
汪颖1,†(), 李沛霖1, 李泉1, 狄红梅1, 高昶1   
  1. 1. 100038　北京，首都医科大学附属复兴医院消化内科
  • 收稿日期:2023-01-06 出版日期:2023-02-15
  • 通信作者: 汪颖
  • 基金资助:
    首都医科大学附属复兴医院重点培育基金(PY-Z-202201)

Study on the effectiveness of exhaled breath NO monitoring in the diagnosis of Helicobacter pylori infection

Ying Wang1,†(), Peilin Li1, Quan Li1, Hongmei Di1, Chang Gao1   

  1. 1. Department of Gastroenterology, The affiliated Fu Xing Hospital of Capital Medical University, 100038 Beijing, China
  • Received:2023-01-06 Published:2023-02-15
  • Corresponding author: Ying Wang
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引用本文：

汪颖, 李沛霖, 李泉, 狄红梅, 高昶. 呼出气一氧化氮监测诊断幽门螺杆菌感染的有效性研究[J]. 中华胃肠内镜电子杂志, 2023, 10(01): 37-40.

Ying Wang, Peilin Li, Quan Li, Hongmei Di, Chang Gao. Study on the effectiveness of exhaled breath NO monitoring in the diagnosis of Helicobacter pylori infection[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2023, 10(01): 37-40.

目的

分析呼出气一氧化氮(NO)监测诊断幽门螺杆菌试验的有效性。

方法

回顾性分析2022年1月至2022年12月首都医科大学附属复兴医院消化科收治的182例患者的临床资料，比较呼出气NO监测与金标准内镜下黏膜活检幽门螺杆菌试验的灵敏度与特异度。

结果

共纳入患者182例，其中，男79例、女103例，中位年龄(53.67±16.16)岁。所有患者均完成内镜检查，剔除4.1%(8/182)未很好配合呼出气NO监测检查的患者。同期内镜下黏膜活检幽门螺杆菌试验28.2%(49/174)，设置患者NO呼出值>10(阳性)与金标准对比，灵敏度为79.6%(39/49)、特异度为80%(100/125)。

结论

呼出气NO监测诊断幽门螺杆菌具有较高的敏感度与特异度，值得做为胃肠道无创监测炎症指标的方法之一。

关键词: 呼出气一氧化氮, 炎症指标, 幽门螺杆菌, 消化系统疾病
Objective

Retrospectively analyze the sensitivity of exhaled nitric oxide (NO) monitoring versus gastroscopic mucosal biopsy Helicobacter pylori test.

Methods

A retrospective analysis was performed for the clinical data of 182 patients admitted to the Department of Gastroenterology, Fuxing Hospital, Capital Medical University from January 2022 to December 2022, and the sensitivity and specificity of exhaled nitric oxide (NO) monitoring and the gold standard endoscopic mucosal biopsy Helicobacter pylori test were compared.

Results

A total of 182 patients were enrolled, including 79 males and 103 females, with an median age of (53.67±16.16) years. All patients underwent endoscopy, but 4.1% (8/182) of them did not complete the examination well with exhaled nitric oxide (NO) monitoring, so 8 patients were excluded. During the same period, the Helicobacter pylori test for endoscopic mucosal biopsy was 28.2% (49/174), and the patient′s NO exhalation value was set to >10 (positive) compared with the gold standard, with a sensitivity of 79.6% (39/49) and a specificity of 80% (100/125).

Conclusion

NO monitoring has high sensitivity and specificity for the diagnosis of Helicobacter pylori, which is worth serving as one of the methods for non-invasive monitoring of gastrointestinal inflammation.

Key words: Exhaled nitric oxide, Inflammation markers, H pylori, Digestive diseases
图1 ROC曲线
表1 呼出气一氧化氮(NO)监测与金标准Hp四格表(例)
金标准Hp NO监测 总计
阳性 阴性
阳性 39 10 49
阴性 25 100 125
合计 64 110 174
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