Fragments produced by different kinds of pancreatic enzymes

doi:10.3877/cma.j.issn.2095-7157.2018.04.007

Abstract

Abstract:

Pancreatic enzymes can enter the small intestine to break down complex nutrients and play a vital role in the digestion and absorption of food. Furthermore, the content and specificity of the digestive enzymes remain under amazing control so that humans can adapt to a wide range of diets. Chronic pancreatitis and other pancreatic diseases can cause pancreatic exocrine dysfunction, leading to maldigestion, steatorrhea and other symptoms. This article will focus on the digestion of protein, fat, carbohydrates and other nutrients by pancreatic enzymes, and the substance fragments formed by different kinds of pancreatic enzymes, which provides a theoretical basis for the early diagnosis and treatment of various pancreatic diseases.

Key words: Pancreas, Pancreatic enzymes, Digestion, Fragments

Yan Wang, Enqiang Linghu. Fragments produced by different kinds of pancreatic enzymes[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2018, 05(04): 174-179.

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References 56

[1]	Zhou Q, Melton DA.Pancreas regeneration[J]. Nature, 2018, 557(7705)：351-358.
[2]	Roxas M. The role of enzyme supplementation in digestive disorders[J]. Altern Med Rev, 2008, 13(4)：307-314.
[3]	Mossner J, Keim V. Pancreatic enzyme therapy[J]. Dtsch Arztebl Int, 2010, 108(34-35)：578-582.
[4]	Altshuler AE, Kistler EB, Schmidschönbein GW.Autodigestion: Proteolytic Degradation and Multiple Organ Failure in Shock[J]. Shock, 2016, 45(5)：483-489.
[5]	Wood EJ.Textbook of biochemistry with clinical correlations (6th edition)[J]. Biochem Mol Biol Edu, 2006, 34(3)：236-237.
[6]	Whitcomb DC, Lowe ME.Human pancreatic digestive enzymes [J]. Dig Dis Sci, 2007, 52(1)：1-17.
[7]	Lieberman M．Mark′s basic medical biochemistry：a clinical approach, 5th ed[M]．Lippincott Williams & Wilkins，2009.
[8]	Whitcomb DC.Acute pancreatitis[J]. N Eng J Med, 2006, 354(20)：2142-2150.
[9]	Gorry MC, Gabbaizedeh D, Furey W, et al.Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis[J]. Gastroenterology, 1997, 113(4)：1063-1068.
[10]	Witt H. A signal peptide cleavage site mutations in the cationic trypsinogen gene is strongly associated with chronic pancreatitis[J]. Gastroenterology, 1999, 117(1)：7-10.
[11]	Whitcomb DC, Gorry MC, Preston RA, et al.Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene[J]. Nat Genet, 1996, 14(2)：141-145.
[12]	Pfützer R , Myers E, Applebaumshapiro S, et al.Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis[J]. Gastroenterology, 2001, 120(5)：271-272.
[13]	Whitcomb DC.Value of genetic testing in the management of pancreatitis[J]. Gut, 2004, 53(11)：1710-1717.
[14]	Frick TW, Fernández-del Castillo C, Bimmler D, et al.Elevated calcium and activation of trypsinogen in rat pancreatic acini[J]. Gut, 1997, 41(3)：339-343.
[15]	Sutton R, Criddle D, Raraty MG, et al.Signal Transduction, Calcium and Acute Pancreatitis[J]. Pancreatology, 2003, 3(6)：497-505.
[16]	Bishop MD, Freedman SD, Zielenski J, et al.The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis[J]. Hum Genet, 2005, 118(3-4)：372-381.
[17]	Alazmi WM, Fogel EL, Schmidt S, et al.ERCP findings in idiopathic pancreatitis：patients who are cystic fibrosis gene positive and negative[J]. Gastrointest Endosc, 2006, 63(2)：234-239.
[18]	Jahan-Mihan A, Luhovyy BL, El Khoury D, et al.Dietary proteins as determinants of metabolic and physiologic functions of the gastrointestinal tract[J]. Nutrients, 2011, 3(5)：574-603.
[19]	Carrere J, Figarella C, Guy O, et al.Human pancreatic chymotrypsinogen A：a non-competitive enzyme immunoassay, and molecular forms in serum and amniotic fluid[J]. Biochim Biophys Acta, 1986, 883(1)：46-53.
[20]	Mohapatra S, Majmunder S, Smyrk TC, et al.Diabetes mellitus is associated with an exocrine pancreatopathy：conclusions from a review of the literature[J]. Pancreas, 2016, 45(8)：1104-1110.
[21]	Zsori G, Illes D, Terzin V, et al.Exocrine pancreatic insufficiency in type 1 and type 2 diabetes mellitus：do we need to treat it A systematic review[J]. Pancreatology, 2018, 18(5)：559-565.
[22]	Binder HJ, Reuben A. Nutrient digestion and absorption[M]//Boron WF, Boulpaep EL.Medical Physiology：a Cellular and Molecular Approach.Philadelphia，PA：Saunders，2009：949-979.
[23]	Adibi SA, Gray SJ, Menden E. The kinetics of amino acid absorption and alteration of plasma composition of free amino acids after intestinal perfusion of amino acid mixtures[J]. Am J Clin Nutr, 1967, 20(1)：24-33.
[24]	Capriotti AL, Caruso G, Cavaliere C, et al.Identification of potential bioactive peptides generated by simulated gastrointestinal digestion of soybean seeds and soy milk proteins[J]. J Food Compos Anal, 2015, 44：205-213.
[25]	Admassu H, Gasmalla M, Yang R, et al.Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits：Antihypertensive, Antioxidant, and Antidiabetic Properties[J]. J Food Sci, 2017, 83(1)：6-16.
[26]	Beaulieu L, Sirois M, Tamigneaux.Evaluation of the in vitro biological activity of protein hydrolysates of the edible red alga, Palmaria palmata (dulse) harvested from the Gaspe coast and cultivated in tanks[J]. J Appl Phycol, 2016, 28(5)：1-15.
[27]	Carey MC.Digestion and absorption of fat[C]．Semin Gastrointest Dis，1992，3：189-208.
[28]	Van Tilbeurgh H, Gargouri Y, Dezan C, et al.Crystallization of pancreatic procolipase and of its complex with pancreatic lipase[J]. J Mol Biol, 1993, 229(2)：552-554.
[29]	Borgstroem B. Influence of bile salt, PH, and time on the action of pancreatic lipase; physiological implications[J]. J Lipid Res, 1964, 5：522-531.
[30]	Pongprasobchai S. Maldigestion from pancreatic exocrine insufficiency[J]. J Gastroenterol Hepatol, 2013, 28(S4)：99-102.
[31]	Dimagno EP, Go VL, Summerskill WH.Relations between pancreatic enzyme ouputs and malabsorption in severe pancreatic insufficiency[J]. N Engl J Med, 1973, 288(16)：813-815.
[32]	Toouli J, Brooke-Smith M, Bassi C, et al.Guidelines for the management of acute pancreatitis[J]. J Gastroenterol Hepatol, 2002, 17(s1)：515-539.
[33]	Borgstrom B, Dahlqvist A, Lundh G, et al.Studies of intestinal digestion and absorption in the human[J]. J Clin Invest, 1957, 36(10)：1521-1536.
[34]	Van Den Bosch H, Postema NM, De Haas GH, et al.On the positional specificity of phospholipase A from pancreas[J]. Biochim Biophys Acta, 1965, 98(3)：657-659.
[35]	Bach AC, Babayan VK.Medium-chain triglycerides：an update[J]. Am J Clin Nutr, 1982, 36(5)：950-962.
[36]	Maldonadovalderrama J, Wilde P, Macierzanka A, et al.The role of bile salts in digestion[J]. Adv Colloid Interfac Advances in Colloid & Interface Science, 2011, 165(1)：36-46.
[37]	Huggins KW, Boileau AC, Hui DY.Protection against diet-induced obesity and obesity-related insulin resistance in Group 1B PLA2-deficient mice[J]. Am J Physiol Endocrinol Metab, 2002, 283(5)：E994-E1001.
[38]	Iqbal J, Hussain MM.Intestinal lipid absorption[J]. Am J Physiol Endocrinol Metab, 2009, 296(6)：E1183-E1194.
[39]	McIntyre N．Cholesterol Absorption[M]//Rommel K, Goebell H., Bohmer R.. Lipid absorption：biochemical and clinical aspects. London：MTP Press Ltd.，1976：73-84.
[40]	Feinle-Bisset C, Azpiroz F. Dietary lipids and functional gastrointestinal disorders[J]. Am J Gastroenterol, 2013, 108(5)：737-747.
[41]	Ebert EC.Maldigestion and malabsorption[J]. Dis Mon, 2001, 47(2): 49-68.
[42]	Devlin TM.Textbook of Biochemistry with Clinical Correlations[M]. Hoboken，NJ：Wiley-Liss，2006：529-571.
[43]	Lieberman M, Marks AD.Basic Medical Biochemistry：a Clinical Approach[M]．Baltimore，MD：Lippincott，Williams and Wilkins，2009：395-396.
[44]	Goodman BE.Insights into digestion and absorption of major nutrients in humans[J]. Adv Physiol Educ, 2010, 34(2)：44-53.
[45]	Campbell I. Digestion and absorption[J]. Anaesth Intens Car, 2009, 10(7)：342-343.
[46]	Abrams Ck Fau-Hamosh M, Hamosh M Fau-Dutta SK, Dutta Sk Fau-Hubbard VS, et al.Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency[J]. Gastroenterology, 1987, 92(1)：125-129.
[47]	Beck IT.The role of pancreatic enzymes in digestion[J]. Am J Clin Nutr, 1973, 26(3)：311-325.
[48]	Gray GM.Carbohydrate digestion and absorption. Role of the small intestine[J]. N Engl J Med, 1975, 292(23)：1225-1230.
[49]	Alpers DH.Digestion and absorption of carbohydrates and proteins[M].1987：1469-1487.
[50]	Omer A, Quigley E. Carbohydrate Maldigestion and Malabsorption [J]. Clin Gastroenterol & H, 2018, 16(8)：1197-1199.
[51]	Lebenthal E, Lee PC.Development of functional response in human exocrine pancreas[J]. Pediatrics, 1980, 66(4)：556-560.
[52]	Lankisch PG, Otto J. Salivary isoamylase in duodenal aspirates[J]. Dig Dis Sci, 1986, 31(12)：1299-1302.
[53]	Sjolund K, Haggmark A, Ihse I, et al.Selective deficiency of pancreatic amylase[J]. Gut, 1991, 32(5)：546-548.
[54]	Lowe CU, May CD.Selective pancreatic deficiency, absent amylase, diminished trypsin, and normal lipase[J]. AMA Am J Dis Child, 1951, 82(4)：459-464.
[55]	Mehta DI, Wang HH, Akins RE, et al.Isolated pancreatic amylase deficiency: probable error in maturation[J]. J Pediatr, 2000, 136(6)：844-846.
[56]	Singh VK, Haupt ME, Geller DE, et al.Less common etiologies of exocrine pancreatic insufficiency[J]. World J Gastroenterol, 2017, 23(39): 7059-7076.

酶		作用位点及产物
内肽酶		?
?	胰蛋白酶	水解内部赖氨酸或精氨酸键，产生寡肽；活化其他酶原
?	糜蛋白酶	水解内部芳香族氨基酸键(如苯丙氨酸、酪氨酸和色氨酸)，产生寡肽
?	弹性蛋白酶	水解中性脂肪族氨基酸肽键，产生寡肽
外肽酶		?
?	羧肽酶A	水解蛋白质与多肽羧基端芳香族氨基酸，产生芳香族氨基酸与肽类
?	羧肽酶B	水解蛋白质与多肽羧基端赖氨酸或精氨酸残基，产生精氨酸、赖氨酸与肽类

酶		作用位点及产物
内肽酶		?
?	胰蛋白酶	水解内部赖氨酸或精氨酸键，产生寡肽；活化其他酶原
?	糜蛋白酶	水解内部芳香族氨基酸键(如苯丙氨酸、酪氨酸和色氨酸)，产生寡肽
?	弹性蛋白酶	水解中性脂肪族氨基酸肽键，产生寡肽
外肽酶		?
?	羧肽酶A	水解蛋白质与多肽羧基端芳香族氨基酸，产生芳香族氨基酸与肽类
?	羧肽酶B	水解蛋白质与多肽羧基端赖氨酸或精氨酸残基，产生精氨酸、赖氨酸与肽类

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