Research progress of long noncoding RNA in gastrointestinal stromal tumor

doi:10.3877/cma.j.issn.2095-7157.2022.03.008

Abstract

Abstract:

Long noncoding RNA (lncRNA), a class of transcripts with a length of more than 200 nucleotides, noncoding RNAs (ncRNA) that regulate gene expression but do not exhibit any protein coding function, has become a new hot topic following the microRNA study. lncRNA uses three main modes of action: modification, guidance, and scaffolding to participate in the regulation of digestive system tumor progression through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other mechanisms. Gastrointestinal Stromal Tumor(GIST)are the most common mesenchymal-derived tumors of the digestive tract, mainly due to mutations in the kit gene or the Platelet-Derived Growth Factor Receptor alpha (PDGFRα) gene. This article reviews the role of lncRNA in the pathogenesis of gastrointestinal stromal tumor.

Key words: Gastrointestinal stromal tumor, Long noncoding RNA, Review

Fulai Gao, Dongqiang Zhao. Research progress of long noncoding RNA in gastrointestinal stromal tumor[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2022, 09(03): 152-155.

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