Clinical features in the patients with hepatic amyloidosis

doi:10.3877/cma.j.issn.2095-7157.2020.03.005

Abstract

Abstract:

Objective

To summarize the clinical characteristics of patients with amyloidosis and guide the clinical diagnosis and treatment.

Methods

The clinical data of 12 patients with amyloidosis confirmed by pathological biopsy in Beijing You′an Hospital from January 2009 to December 2017 were retrospectively analyzed.

Results

There were 9 males and 3 females with an average age of (56±8) years (range, 39-70 years). Clinical manifestations: fatigue in 5 cases, poor appetite in 4 cases, abdominal distension in 6 cases, abdominal pain in 6 cases, ascites in 6 cases, hepatomegaly in 6 cases, splenomegaly in 4 cases. Laboratory examination: 6 cases of abnormal liver function, 4 cases of abnormal transaminase, 4 cases of elevated bilirubin, 10 cases of elevated gamma glutamyltranspeptidase, 10 cases of elevated alkaline phosphatase, 8 cases of hypoalbuminemia, 8 cases of proteinuria, 2 cases of hematuria, 6 cases of anemia.

Conclusion

Amyloidosis is more common in men with various clinical manifestations and liver and kidney damage, which is usually diagnosed by pathological biopsy.

Key words: Amyloidosis, Liver injury, Renal injury, Pathological biopsy

Wen Gao, Rui Zhong, Man Zhao, Dongmei Wang, Weiwei Kang, Lili Feng, Hongbo Ma, Lieqing Ma. Clinical features in the patients with hepatic amyloidosis[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2020, 07(03): 126-129.

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Figures/Tables 3

References 13

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项目			构成比/发生率[n(%)]	均数±标准差	范围
血红蛋白(g/L)			?	126±31.3	78～177
?		≤60	0(0)	?	?
?		≤90	1(8.33)	?	?
?		≤120	5(41.6)	?	?
白细胞(×10⁹/L)			?	7.32±1.57	4.5～9.23
血小板(×10⁹/L)			?	246±151	36～477
?		≤400	10(83.3)	?	?
?		>400	2(16.7)	?	?
血肌酐(μmol/L)			?	126.7±72.3	48～274.3
?		≥97	6(50)	?	?
AST(u/L)			?	33±17.7	12～66.8
?		≥40	4(33.3)	?	?
总胆红素(μmol/L)			?	77.3±156	6.1～538
直接胆红素(μmol/L)			?	33.6±67	3～224
γ谷氨酰转肽酶(U/L)			?	757.8±966	38～3128
碱性磷酸酶(U/L)			?	413.3±241.9	84～847.6
C反应蛋白(mg/L)			?	1.3±1.6	0.3～2.7
凝血酶原活动度(%)			5(41.67)	?	?
?	<80		5(41.67)	?	?
尿蛋白阳性(g/L)			3(25)	1.46±10.3	0.08～3.54
?	>1		3(25)	1.46±10.3	0.08～3.54

项目			构成比/发生率[n(%)]	均数±标准差	范围
血红蛋白(g/L)			?	126±31.3	78～177
?		≤60	0(0)	?	?
?		≤90	1(8.33)	?	?
?		≤120	5(41.6)	?	?
白细胞(×10⁹/L)			?	7.32±1.57	4.5～9.23
血小板(×10⁹/L)			?	246±151	36～477
?		≤400	10(83.3)	?	?
?		>400	2(16.7)	?	?
血肌酐(μmol/L)			?	126.7±72.3	48～274.3
?		≥97	6(50)	?	?
AST(u/L)			?	33±17.7	12～66.8
?		≥40	4(33.3)	?	?
总胆红素(μmol/L)			?	77.3±156	6.1～538
直接胆红素(μmol/L)			?	33.6±67	3～224
γ谷氨酰转肽酶(U/L)			?	757.8±966	38～3128
碱性磷酸酶(U/L)			?	413.3±241.9	84～847.6
C反应蛋白(mg/L)			?	1.3±1.6	0.3～2.7
凝血酶原活动度(%)			5(41.67)	?	?
?	<80		5(41.67)	?	?
尿蛋白阳性(g/L)			3(25)	1.46±10.3	0.08～3.54
?	>1		3(25)	1.46±10.3	0.08～3.54

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