In this study, we compared the effectiveness and safety of the portable disposable large-channel endoscope and a conventional gastroscope in hemostasis and endoscopic submucosal dissection (ESD).

Rabbits were treated with debridement and hemostasis after general anesthesia. After constructing the model of gastrorrhagia, the endoscopic surgeons randomly selected a gastroscope to debridement the bleeding site and spray hemostatic powder to achieve hemostasis. We will compare the overall operation time, the amount of hemostatic powder, the success rate of hemostasis and the times of plugging of the powder delivery tube between the two groups. Overall operation time, the amount of hemostatic powder, the success rate of hemostasis and the times of plugging of the powder delivery tube were compared between the 2 types of endoscopes. Bama pigs would receive ESD treatment after general anesthesia. The experiment was completed by experienced endoscopic physicians. Total duration of ESD, success rate of en bloc resection, perforation rate, device failure rate, satisfaction with the use of endoscope system and picture rating were compared between the 2 types of endoscopes.

Both groups successfully completed hemostasis. There was no difference between the dosage of hemostatic powder in the experimental group (2.54±0.97) g and that in the control group (2.25±0.79) g. The powder delivery tube in the control group was blocked once. In the overall operation time, the experimental group (86.62±13.68) s was significantly shorter than that in the control group (101.75±17.14) s, with P value=0.004. Both groups completed 16 ESDs. There were no significant differences between the total duration of ESD in the experimental group (19.22±9.50) min and that in the control group (17.72±5.15) min, with P value =0.985. There were no differences in success rate of en bloc resection and picture rating between the 2 types of gastroscopes. Neither of the gastroscopes caused perforation during ESD. There was no failure of the instruments in both groups. The satisfactions evaluation of two groups were basically satisfactory and above.

The portable disposable large-channel digestive endoscope could perform gastroscopy and treatment effectively, which is of great significance in reducing infection and breaking the restriction of the use of endoscope.