目的

通过胃癌患者行超级微创手术(SMIS)与器官切除式手术(ORS)炎症因子对比,评估SMIS 对人体的影响。

方法

前瞻性随机纳入2023 年5 月至2024 年4 月解放军总医院消化内科医学部行SMIS 手术20 例胃癌患者,解放军总医院普通外科医学部行ORS 手术20 例胃癌患者,应用酶联免疫吸附试验检测术前1 d 和术后3 d 血清样本中肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-1β(IL-1β)、白介素-4(IL-4)、白介素-10(IL-10)、转化生长因子-β(TGF-β),6 种炎症因子浓度的变化情况。

结果

SMIS 治疗的胃癌患者术前术后6 种炎症因子浓度变化无统计学差异(P>0.05),ORS 治疗的胃癌患者术前术后6 种炎症因子浓度变化无统计学差异(P>0.05)。

结论

SMIS 术后早期炎症反应控制方面与ORS 表现相当,未来研究可延长观察时间窗或纳入更多炎症指标,以更全面地评估不同术式对创伤炎症反应的影响。

Objective

To evaluate the impact of super minimally invasive surgery (SMIS) on the human body by comparing inflammatory factors between gastric cancer patients undergoing SMIS and organ resection surgery (ORS).

Methods

A prospective randomized study included 20 gastric cancer patients who underwent SMIS in the of Department of Gastroenterology from May 2023 to April 2024, and 20 gastric cancer patients who underwent ORS in the General Surgery Department of PLA General Hospital. Enzymelinked immunosorbent assay was used to detect changes in the concentrations of six inflammatory factorstumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), interleukin-4(IL-4),interleukin-10 (IL-10),and transforming growth factor-beta (TGF-β)-in serum samples collected 1 day before surgery and 3 days after surgery.

Results

There were no statistically significant differences in the concentrations of the six inflammatory factors before and after SMIS (P > 0.05), nor were there significant differences before and after ORS (P > 0. 05).

Conclusion

In terms of controlling early postoperative inflammatory responses, SMIS shows comparable performance to ORS. Future studies may extend the observation time window or incorporate more inflammatory indicators to comprehensively evaluate the effects of different surgical procedures on traumatic inflammatory responses.