The study of prevention effect of esomeprazole on clopidogrel-induced gastric mucosal injury

doi:10.3877/cma.j.issn.2095-7157.2018.05.005

Abstract

Abstract:

Objective

To evaluate the prevention effect of esomeprazole on clopidogrel-induced gastric mucosal lesions.

Methods

One hundred and twenty SD rats were divided into three groups randomly, which were intragastric administrated with normal saline, clopidogrel and esomeprazole combined with clopidogrel, respectively.The rats were executed after 7 days, 14 days, 21 days and 28 days, 10 rats for each group each time, then the stomach mucosas were observed and the scores of gastric mucosal injury were evaluated by using Guth system.

Results

Esomeprazole could significantly reduce the incidence of mucosal injury (65.0% vs 42.5%, P=0.044). The scores of ulcer index of combined group were lower than that of clopidogrel group.The degree of injury of combined group did not change significantly over time.

Conclusions

Clopidogrel could induce gastric mucosal injury. Esomeprazole could effectively prevent clopidogrel-induced gastric mucosal injury.

Key words: Esomeprazole, Clopidogrel, Gastric mucosal injury

Shuyi Zhang, Shusen Wang, Mo Dong, Lei Shi, Yanru Li, Wen Li. The study of prevention effect of esomeprazole on clopidogrel-induced gastric mucosal injury[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2018, 05(01): 38-40.

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References 11

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组别	7 d	14 d	21 d	28 d	P值
对照组	0	0	0	0	?
氯吡格雷组	4.22±1.10	6.85±0.99	6.11±1.03	5.51±1.26	<0.001^b
联合组	2.55±1.12	3.56±1.03	3.26±1.09	2.98±1.09	0.212^b
P值	0.003^a	<0.001^a	<0.001^a	<0.001^a	?

组别	7 d	14 d	21 d	28 d	P值
对照组	0	0	0	0	?
氯吡格雷组	4.22±1.10	6.85±0.99	6.11±1.03	5.51±1.26	<0.001^b
联合组	2.55±1.12	3.56±1.03	3.26±1.09	2.98±1.09	0.212^b
P值	0.003^a	<0.001^a	<0.001^a	<0.001^a	?

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