Abstract:

Objective

To observe the effectiveness and safety of Magnesium sulfate and sodium phosphate for bowel preparation before colonoscopy in elderly patients.

Method

A total of 254 elderly patients undergoing colonoscopy in the second medical center of PLA General Hospital were randomly divided into Magnesium sulfate group and sodium phosphate groups.The general information，completion of bowel preparation，adverse reactions，lesion detection rate，incidence of adverse reactions，patient satisfaction and abnormal changes of blood electrolyte after colonoscopy were compared between the two groups.

Result

There was no significant difference in age，gender，body mass index （BMI） between the two groups； After bowel preparation，the average number of bowel movements in the Magnesium sulfate group was （7.9±1.3） times，which was less than that in the sodium phosphate group （9.5±1.9） times，and the difference was statistically significant （P ＜0.05）.The average time required for the magnesium sulfate group to complete bowel preparation was （123.6±23.7） minutes，which was shorter than that of the sodium phosphate group （138.2 ± 25.5） minutes，and the difference was statistically significant （P=0.016）.The total score for Boston bowel preparation of Magnesium sulfate group was （8.11 ± 0.71），slightly higher than that of the sodium phosphate group （7.98 ± 0.69），and the difference was not statistically significant（P＜ 0.05）； The detection rates of bowel polyps and micro polyps （diameter＜5 mm） in the Magnesium sulfate group were 46/128 （35.9%） and 40/128 （31.2%），respectively，which were higher than those in the sodium phosphate group （38/126 （30.1%） and 31/126 （24.6%），and the differences were statistically significant （all P＜0.05）； The incidence of discomfort symptoms such as nausea，abdominal distension，and abdominal pain in the magnesium sulfate group was not significantly different from that in the sodium phosphate group，but the incidence of vomiting was lower than that in the sodium phosphate group，and the difference was statistically significant （P＜0.05）.The satisfaction rate of patients in the Magnesium sulfate group with intestinal preparation reached 95.3%，with no significant difference compared to the sodium phosphate group （96.8%）.The incidence of abnormal blood potassium and phosphorus in the sodium phosphate group was higher than that in the Magnesium sulfate group，while the incidence of abnormal blood Magnesium was higher in the Magnesium sulfate group，and the differences were statistically significant （P＜0.05）.

Conclusion

The use of magnesium sulfate or sodium phosphate in divided oral doses for bowel preparation in elderly patients has good medication compliance and tolerance，high hygiene quality，fewer adverse reactions，and is relatively safe，making it suitable for clinical application.

Key words: Magnesium sulfate, Sodium phosphate, Colonoscopy, Bowel preparation